Antinociceptive and Antioxidant Activities of the Dillenia indica Bark


	International Journal of Pharmacology
	Year: 2012 \| Volume: 8 \| Issue: 4 \| Page No.: 243-251 DOI: 10.3923/ijp.2012.243.251

Antinociceptive and Antioxidant Activities of the Dillenia indica Bark

M. Badrul Alam, M. Saifur Rahman, M. Hasan, M. Maruf Khan, Kamrun Nahar and Sheema Sultana

Abstract: Dillenia indica Linn. (Dilleniaceae) is widely used as food and reputed in the folk medicine of Bangladesh and India in particular, to relieve pain associated with gastrointestinal disturbance. Methanolic extract of the bark of Dillenia indica Linn. (MDI) was subjected to evaluate for its analgesic and antioxidant properties. The analgesic activity of MDI (200 and 400 mg kg^-1 b.wt. p.o.) was determined for its central and peripheral pharmacological actions using hotplate as well as tail immersion method and acetic acid-induced writhing test with formalin induced pain in mice, respectively. To evaluate antioxidant potential of MDI, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as well as total Reactive Oxygen Species (ROS) and assessment of reducing power were used. The extract, at the dose of 200 and 400 mg kg^-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. In DPPH and total ROS scavenging method, MDI showed good antioxidant potentiality with the IC₅₀ value of 12.32±0.16 and 34.72±0.48 μg mL^-1, respectively with a good reducing power. The findings of the study suggested that MDI has strong analgesic and antioxidant effects, conforming the traditional use of this plant for pain alleviation to its antioxidant potentiality.

[Fulltext PDF] [Fulltext HTML] [XML: Abstract + References] [References] [View Citation] [Report Citation]

RELATED ARTICLES:

•	Phytochemical Evaluation and in vitro Free Radical Scavenging Activity of Cold and Hot Successive Pseudobulb Extracts of Medicinally Important Orchid Flickingeria nodosa (Dalz.) Seidenf

•	Chervil: A Multifunctional Miraculous Nutritional Herb

•	Antioxidant, Anti-inflammatory and Anti-pyretic Activities of Trichosanthes dioica Roxb. Fruits

•	Analgesic and Antioxidant Properties of Ethanolic Extract of Terminalia catappa L. Leaves

•	Evaluation of Phytochemical and Pharmacological Properties of Dillenia indica Linn. Leaves

•	Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Aerial Parts of Justicia gendarussa Burm.

How to cite this article:

M. Badrul Alam, M. Saifur Rahman, M. Hasan, M. Maruf Khan, Kamrun Nahar and Sheema Sultana, 2012. Antinociceptive and Antioxidant Activities of the Dillenia indica Bark. International Journal of Pharmacology, 8: 243-251.

DOI: 10.3923/ijp.2012.243.251

URL: https://scialert.net/abstract/?doi=ijp.2012.243.251

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		SCOPUS
		Thomson ISI