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Journal of Pharmacology and Toxicology
  Year: 2010 | Volume: 5 | Issue: 5 | Page No.: 222-228
DOI: 10.3923/jpt.2010.222.228
 
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Evaluation of Phytochemical and Pharmacological Properties of Dillenia indica Linn. Leaves

U. Bose, K. Gunasekaran, V. Bala and A.A. Rahman

Abstract:
The crude methanol extract of the roots of Dillenia indica Linn. (Family: Dilleniaceae) was investigated for its possible analgesic, antidiarrhoeal and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg kg-1 b.wt. (p<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg kg-1 of body weight. The crude extract produced significant antidiarrhoeal effect at the dose of 500 mg kg-1 of body weight comparable to that produced by loperamide, used as standard drug. The extract also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI tract in comparison to control animals. This study has found a base stone to step ahead for further researches to make them pharmaceutically useful.
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How to cite this article:

U. Bose, K. Gunasekaran, V. Bala and A.A. Rahman, 2010. Evaluation of Phytochemical and Pharmacological Properties of Dillenia indica Linn. Leaves. Journal of Pharmacology and Toxicology, 5: 222-228.

DOI: 10.3923/jpt.2010.222.228

URL: https://scialert.net/abstract/?doi=jpt.2010.222.228

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