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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 6 | Page No.: 910-915
DOI: 10.3923/ijp.2010.910.915
 
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Analgesic and Antioxidant Properties of Ethanolic Extract of Terminalia catappa L. Leaves

H.V. Annegowda, M.N. Mordi, S. Ramanathan and S.M. Mansor

Abstract:
The aim of the present study was to investigate the analgesic and antioxidant activities of ethanolic extract of Terminalia catappa (TCSE) leaves obtained by soxhlet extraction. The analgesic effects of TCSE extract was studied by formalin induced pain, hot plate and tail flick tests where as antioxidant activity was evaluated by ABTS radical scavenging and metal chelating assays. In formalin test, 80 mg kg-1 (p.o.) dose of TCSE extract inhibited both the phases (p<0.05) of animal’s nociception, but TCSE extracts (40 mg kg-1, p.o.) inhibited only late phase. TCSE extract (80 mg kg-1, p.o.) showed a significant (p<0.05) increase in the reaction time in hot plate test at the time interval of 60, 90 and 120 min. In contrast, both the doses of TCSE extracts did not show any analgesic effect in tail flick test, but morphine (5 mg kg-1, s.c.) shown significantly (p<0.05) higher analgesic effect at all time intervals. TCSE extracts showed moderate ABTS free radical scavenging activity compared to standard gallic acid and higher activity compared to BHT (88.07, 96.35 and 68.76% of inhibition, respectively) but shown less ability to chelate ferrous ion. It was concluded from our studies that TCSE extracts have analgesic and anti-inflammatory properties as well as better radical scavenging ability.
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How to cite this article:

H.V. Annegowda, M.N. Mordi, S. Ramanathan and S.M. Mansor, 2010. Analgesic and Antioxidant Properties of Ethanolic Extract of Terminalia catappa L. Leaves. International Journal of Pharmacology, 6: 910-915.

DOI: 10.3923/ijp.2010.910.915

URL: https://scialert.net/abstract/?doi=ijp.2010.910.915

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