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Asian Journal of Biochemistry

Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 409-414
Research Article

The Protective Nature of Garlic, Ginger and Vitamin E on CCl4-Induced Hepatotoxicity in Rats

K.C. Patrick-Iwuanyanwu
Department of Biochemistry, Toxicological Unit, University of Port Harcourt, P.M.B. 5323 Choba, Port Harcourt Rivers State, Nigeria
M.O. Wegwu
Department of Biochemistry, Toxicological Unit, University of Port Harcourt, P.M.B. 5323 Choba, Port Harcourt Rivers State, Nigeria
E.O. Ayalogu
Department of Biochemistry, Toxicological Unit, University of Port Harcourt, P.M.B. 5323 Choba, Port Harcourt Rivers State, Nigeria
The protective nature of garlic, ginger and vitamin E on CCl4-induced liver damage in rats were investigated using selected haematological indices: PCV, Hb, WBC, polymorphonuclear cells and lymphocytes. PCV was lowest in rats administered garlic-ginger (1:2) and CCl4 (0.5 mL kg-1 bw) with a mean value of 28.7%. However, highest PCV values were obtained in rats that were given rat pellets alone without CCl4.Hb of rats pre-treated with vitamin E recorded the lowest mean value while rats treated with garlic and ginger (2:1) only, recorded the highest mean value of 101.2 g dL-1). Hb levels were increased in rats pre-treated with ginger, garlic and ginger (1:1), garlic and ginger (1:2). CCl4 treatment caused an elevation of WBC in rats pre-treated with garlic, ginger, vitamin E and mixtures of garlic and ginger. This increase was observed to be highest in rats treated with a mixture of CCl4, garlic and ginger (1:2) (10860 mm-3 L-1). However, rats in the group treated with feed only without CCl4 recorded the lowest WBC. Among the groups injected with CCl4, a lower WBC value of 6200 mm-3 L-1 was recorded in the group fed vitamin E. These findings suggest that the pre-treatment of rats with mixtures of garlic and ginger prior to CCl4-administration would result in an increase in the PCV and Hb values and a decrease in WBC values.
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