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Asian Journal of Biochemistry
  Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 409-414
DOI: 10.3923/ajb.2007.409.414
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The Protective Nature of Garlic, Ginger and Vitamin E on CCl4-Induced Hepatotoxicity in Rats

K.C. Patrick-Iwuanyanwu , M.O. Wegwu and E.O. Ayalogu

The protective nature of garlic, ginger and vitamin E on CCl4-induced liver damage in rats were investigated using selected haematological indices: PCV, Hb, WBC, polymorphonuclear cells and lymphocytes. PCV was lowest in rats administered garlic-ginger (1:2) and CCl4 (0.5 mL kg-1 bw) with a mean value of 28.7%. However, highest PCV values were obtained in rats that were given rat pellets alone without CCl4.Hb of rats pre-treated with vitamin E recorded the lowest mean value while rats treated with garlic and ginger (2:1) only, recorded the highest mean value of 101.2 g dL-1). Hb levels were increased in rats pre-treated with ginger, garlic and ginger (1:1), garlic and ginger (1:2). CCl4 treatment caused an elevation of WBC in rats pre-treated with garlic, ginger, vitamin E and mixtures of garlic and ginger. This increase was observed to be highest in rats treated with a mixture of CCl4, garlic and ginger (1:2) (10860 mm-3 L-1). However, rats in the group treated with feed only without CCl4 recorded the lowest WBC. Among the groups injected with CCl4, a lower WBC value of 6200 mm-3 L-1 was recorded in the group fed vitamin E. These findings suggest that the pre-treatment of rats with mixtures of garlic and ginger prior to CCl4-administration would result in an increase in the PCV and Hb values and a decrease in WBC values.
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  •    Preliminary Study on the Antioxidative and Anti-Fungal Effects of Ginger Oil on the Shelf Life of Hot Smoked Fish
  •    Effects of 1-O-hexyl-2, 3, 5-trimethylhydroquinone in Carbon Tetrachloride-induced Hepatic Apoptosis with a Possible Relationship to Naofen
  •    Anti-Oxidative and Anti-fungal Effects of Fresh Ginger (Zingiber officinale) Treatment on the Shelf Life of Hot-smoked Catfish (Clarias gariepinus, Burchell, 1822)
  •    Isolation and Characterization of a Potent Protein from Ginger Rhizomes Having Multiple Medicinal Properties
How to cite this article:

K.C. Patrick-Iwuanyanwu , M.O. Wegwu and E.O. Ayalogu , 2007. The Protective Nature of Garlic, Ginger and Vitamin E on CCl4-Induced Hepatotoxicity in Rats . Asian Journal of Biochemistry, 2: 409-414.

DOI: 10.3923/ajb.2007.409.414






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