Asian Journal of Biochemistry 1815-9923 1815-9931 Academic Journals Inc. 10.3923/ajb.2007.409.414 4-Induced Hepatotoxicity in Rats]]> Patrick-Iwuanyanwu K.C. Wegwu M.O. Ayalogu E.O. 6 2007 2 6 The protective nature of garlic, ginger and vitamin E on CCl4-induced liver damage in rats were investigated using selected haematological indices: PCV, Hb, WBC, polymorphonuclear cells and lymphocytes. PCV was lowest in rats administered garlic-ginger (1:2) and CCl4 (0.5 mL kg-1 bw) with a mean value of 28.7%. However, highest PCV values were obtained in rats that were given rat pellets alone without CCl4.Hb of rats pre-treated with vitamin E recorded the lowest mean value while rats treated with garlic and ginger (2:1) only, recorded the highest mean value of 101.2 g dL-1). Hb levels were increased in rats pre-treated with ginger, garlic and ginger (1:1), garlic and ginger (1:2). CCl4 treatment caused an elevation of WBC in rats pre-treated with garlic, ginger, vitamin E and mixtures of garlic and ginger. This increase was observed to be highest in rats treated with a mixture of CCl4, garlic and ginger (1:2) (10860 mm-3 L-1). However, rats in the group treated with feed only without CCl4 recorded the lowest WBC. Among the groups injected with CCl4, a lower WBC value of 6200 mm-3 L-1 was recorded in the group fed vitamin E. These findings suggest that the pre-treatment of rats with mixtures of garlic and ginger prior to CCl4-administration would result in an increase in the PCV and Hb values and a decrease in WBC values.

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