Zulia Setiyaningrum
Magister Science of Nutrition Programe, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
S.S. Darmono
Department Science of Nutrition, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
Muchlis Achsan Udji Sofro
Department of Internal Medicine, Dr Kariadi Hospital, Semarang, Indonesia
Edi Dharmana
Department of Clinical Parasitology, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
Nyoman Suci Widyastiti
Departement of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
ABSTRACT
Patients with pulmonary tuberculosis generally malnourished due to side effect in anti-tuberculosis drugs, which altering gastrointestinal tract, it affects on recovery process, immune system and response. Probiotics and zinc are thought to have beneficial effects for nutritional status and immune response. This study was conducted to analyze the effect of combined probiotics and zinc on levels of lymphocytes, neutrophils lymphocyte count ratio (NLR) and monocytes in patients with pulmonary tuberculosis in Lung Health Center of Semarang. In a quasi-experimental study (quasi experiment) randomized design with pre-post test control group design, fifty four pulmonary tuberculosis patients were divided into 2 groups, the treatment group received a combination of probiotics and zinc, as well as a control group given a placebo, administration for 4 weeks. There were no differences in mean age, levels of lymphocytes and monocytes NLR at baseline (p>0.05). Increased levels of lymphocytes and decreased levels of monocytes and NLR after administration of the combination of probiotics and zinc (p<0.05). There was no significant relationship between nutriens intake with high levels of lymphocytes, NLR and monocytes (p>0.05). The most powerful effectiveness of the combination probiotics and zinc contained in the lymphocyte levels (12.8%). It is concluded that the combined probiotics and zinc over 4 weeks improve the immune system of patients with pulmonary tuberculosis measured by lymphocytes, NLR and monocytes.
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How to cite this article
Zulia Setiyaningrum, S.S. Darmono, Muchlis Achsan Udji Sofro, Edi Dharmana and Nyoman Suci Widyastiti, 2016. Effect of Combined Probiotics and Zinc Supplementation on Immune Status of Pulmonary Tuberculosis Patients. Pakistan Journal of Nutrition, 15: 680-685.
DOI: 10.3923/pjn.2016.680.685
URL: https://scialert.net/abstract/?doi=pjn.2016.680.685
DOI: 10.3923/pjn.2016.680.685
URL: https://scialert.net/abstract/?doi=pjn.2016.680.685
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