Kashif-ur-Rehman Khan
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand
Chitchamai Ovatlarnporn
Drug Delivery System Excellence Center, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand
ABSTRACT
Hydroxypropyl cellulose (HPC) was selected as a macromolecular carrier for the attachment of para-aminobenzoic acid (PABA) for different pharmaceutical, biomedical and nutritional applications. HPC-PABA ester conjugate was synthesized in a two easy steps that were performed homogeneously. In the first step, the primary amino group of PABA was protected by 98% formic acid and during the second step the protected PABA was coupled with the HPC polymer in DMF by using 4-(dimethylamino)pyridine as a base and N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC.HCl) as a coupling reagent at room temperature. The optimum conditions for deprotection process were also determined. Novel macromolecular conjugate has solubility in both water and organic solvents. HPC-PABA ester conjugate was synthesized with good percentage yield and purity and well identified by FT-IR and 1H-NMR techniques. According to this new synthesis plan HPC-PABA conjugate can be prepared easily and has potential for pharmaceutical, textile and biomedical sectors.
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How to cite this article
Kashif-ur-Rehman Khan and Chitchamai Ovatlarnporn, 2016. Synthesis and Evaluation of p-Aminobenzoylhydroxypropyl Cellulose. Pakistan Journal of Nutrition, 15: 725-728.
DOI: 10.3923/pjn.2016.725.728
URL: https://scialert.net/abstract/?doi=pjn.2016.725.728
DOI: 10.3923/pjn.2016.725.728
URL: https://scialert.net/abstract/?doi=pjn.2016.725.728
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