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Pakistan Journal of Nutrition
  Year: 2016 | Volume: 15 | Issue: 8 | Page No.: 725-728
DOI: 10.3923/pjn.2016.725.728
 
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Synthesis and Evaluation of p-Aminobenzoylhydroxypropyl Cellulose

Kashif-ur-Rehman Khan and Chitchamai Ovatlarnporn

Abstract:
Hydroxypropyl cellulose (HPC) was selected as a macromolecular carrier for the attachment of para-aminobenzoic acid (PABA) for different pharmaceutical, biomedical and nutritional applications. HPC-PABA ester conjugate was synthesized in a two easy steps that were performed homogeneously. In the first step, the primary amino group of PABA was protected by 98% formic acid and during the second step the protected PABA was coupled with the HPC polymer in DMF by using 4-(dimethylamino)pyridine as a base and N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC.HCl) as a coupling reagent at room temperature. The optimum conditions for deprotection process were also determined. Novel macromolecular conjugate has solubility in both water and organic solvents. HPC-PABA ester conjugate was synthesized with good percentage yield and purity and well identified by FT-IR and 1H-NMR techniques. According to this new synthesis plan HPC-PABA conjugate can be prepared easily and has potential for pharmaceutical, textile and biomedical sectors.
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How to cite this article:

Kashif-ur-Rehman Khan and Chitchamai Ovatlarnporn, 2016. Synthesis and Evaluation of p-Aminobenzoylhydroxypropyl Cellulose. Pakistan Journal of Nutrition, 15: 725-728.

DOI: 10.3923/pjn.2016.725.728

URL: https://scialert.net/abstract/?doi=pjn.2016.725.728

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