O.B. Bolaji
Department of Paediatrics and Child Health, Federal Teaching Hospital, Ido-Ekiti, Ekiti State, Nigeria
V.O. Adebara
Department of Paediatrics and Child Health, Federal Teaching Hospital, Ido-Ekiti, Ekiti State, Nigeria
O.J. Adebami
Department of Paediatrics and Child Health, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Nigeria
J.A. Owa
Department of Paediatrics and Child Health, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
ABSTRACT
Maternal zinc deficiency is associated with fetal growth retardation and fetal malnutrition (FM). FM is common in developing countries. The main aim of the current study was to determine the association between maternal serum zinc levels and FM. After receiving hospital ethics committee approval and informed consent from the mothers, consecutive pregnant women and their respective live, singleton, term babies delivered between August 2013 and January 2014 at the Federal Teaching Hospital Ido-Ekiti in south western Nigeria were included in our study. Pregnancy and antenatal records were obtained. Maternal serum zinc levels were assayed and babies were examined for FM within 24 h of birth. FM was diagnosed using the Clinical Assessment of Fetal Nutritional Status Score as adapted by Metcoff. Maternal serum zinc levels were stratified and compared among mothers who had babies with and without FM. A total number of 386 babies were studied, 90 (23.3%) had FM. The mean [±standard deviation (SD)] maternal serum zinc concentration was 9.0 (±6.1) μmol/L and 187 (48.4%) mothers had hypozincemia. The mean (±SD) serum zinc concentration of mothers of babies with FM was 7.4 (±5.3) μmol/L compared to 9.5 (±6.2) μmol/L for mothers of babies without FM (p = 0.003). Fifty-eight (64.4%) mothers of the 90 babies with FM and 129 (43.6%) of the 296 mothers of babies without FM had hypozincemia (p = 0.001). Although low maternal serum zinc levels were associated with FM, not all mothers with low serum zinc levels had babies with FM and not all babies with FM has mothers with low serum zinc levels. This attests to multifactorial etiology of FM. However, maternal hypozincemia may be a significant contributory factor and, therefore, mothers may benefit from zinc supplementation during pregnancy.
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How to cite this article
O.B. Bolaji, V.O. Adebara, O.J. Adebami and J.A. Owa, 2016. Maternal Serum Zinc Levels and Fetal Malnutrition of Term Babies in Nigeria. Pakistan Journal of Nutrition, 15: 673-679.
DOI: 10.3923/pjn.2016.673.679
URL: https://scialert.net/abstract/?doi=pjn.2016.673.679
DOI: 10.3923/pjn.2016.673.679
URL: https://scialert.net/abstract/?doi=pjn.2016.673.679
REFERENCES
- Adebami, O.J., J.A. Owa, G.A. Oyedeji, O.A. Oyelami and G.O. Omoniyi-Esan, 2007. Associations between placental and cord blood malaria infection and fetal malnutrition in an area of malaria holoendemicity. Am. J. Trop. Med. Hygiene, 77: 209-213.
PubMedDirect Link - Awadallah, S.M., K.H. Abu-Elteen, A.Z. Elkarmi, S.H. Qaraein, N.M. Salem and M.S. Mubarak, 2004. Maternal and cord blood serum levels of zinc, copper and iron in healthy pregnant Jordanian women. J. Trace Elements Exp. Med., 17: 1-8.
CrossRefDirect Link - Adebami, O.J., G.A. Oyedeji, J.A. Owa and O.A. Oyelami, 2007. Prevalence and problems of foetal malnutrition in term babies at Wesley Guild Hospital, South western Nigeria. West Afr. J. Med., 26: 278-282.
PubMedDirect Link - Adebami, O.J., G.A. Oyedeji, J.A. Owa and O.A. Oyelami, 2007. Maternal factors in the etiology of fetal malnutrition in Nigeria. Pediatrics Int., 49: 150-155.
CrossRefPubMedDirect Link - Caulfield, L.E., N. Zavaleta, A.H. Shankar and M. Merialdi, 1998. Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival. Am. J. Clin. Nutr., 68: S499-S508.
Direct Link - Deodhar, J. and R. Jarad, 1999. Study of the prevalence of and high risk factors for fetal malnutrition in term newborns. Ann. Trop. Paediatr.: Int. Child Health, 19: 273-277.
CrossRefDirect Link - Dey, A.C., M. Shahidullah, M.A. Mannan, M.K. Noor, L. Saha and S.A. Rahman, 2010. Maternal and neonatal serum zinc level and its relationship with neural tube defects. J. Health Population Nutr., 28: 343-350.
Direct Link - Fall, C.H.D., C.S. Yajnik, S. Rao, A.A. Davies, N. Brown and H.J.W. Farrant, 2003. Micronutrients and fetal growth. J. Nutr., 133: 1747S-1756S.
PubMedDirect Link - Gibson, R.S. and J.M. Huddle, 1998. Suboptimal zinc status in pregnant Malawian women: Its association with low intakes of poorly available zinc, frequent reproductive cycling and malaria. Am. J. Clin. Nutr., 67: 702-709.
Direct Link - Hotz, C., J.M. Peerson and K.H. Brown, 2003. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: Reanalysis of the second National Health and Nutrition Examination Survey Data (1976-1980). Am. J. Clin. Nutr., 78: 756-764.
Direct Link - IZiNCG., K.H. Brown, J.A. Rivera, Z. Bhutta and R.S. Gibson et al., 2004. International Zinc Nutrition Consultative Group (IZiNCG) technical document# 1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr. Bull., 25: S99-S203.
PubMedDirect Link - Metcoff, J., 1994. Clinical assessment of nutritional status at birth. Fetal malnutrition and SGA are not synonymous. Pediatr. Clin. N. Am., 41: 875-891.
PubMed - Mukherjee, M.D., H.H. Sandstead, M.V. Ratnaparkhi, L.K. Johnson, D.B. Milne and H.P. Stelling, 1984. Maternal zinc, iron, folic acid and protein nutriture and outcome of human pregnancy. Am. J. Clin. Nutr., 40: 496-507.
Direct Link - Neggers, Y.H., G.R. Cutter, R.T. Acton, J.O. Alvarez and J.L. Bonner et al., 1990. A positive association between maternal serum zinc concentration and birth weight. Am. J. Clin. Nutr., 51: 678-684.
Direct Link - Aderinsola, O. and A. Joseph, 2006. Looking for the best indicator fetal malnutrition: An overview. Internet J. Nutr. Wellness, Vol. 3.
Direct Link - Okonofua, F.E., F.A. Amole, W.O. Emofurieta and N.C. Ugwu, 1989. Zinc and copper concentration in plasma of pregnant women in Nigeria. Int. J. Gynecol. Obstet., 29: 19-23.
CrossRefDirect Link - Pathak, P., U. Kapil, S.K. Kapoor, R. Saxena and A. Kumar et al., 2004. Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana. Indian J. Pediatr., 71: 1007-1014.
CrossRefDirect Link - Padmavathi, I.J.N., Y.D. Kishore, L. Venu, M. Ganeshan and N. Harishankar et al., 2009. Prenatal and perinatal zinc restriction: Effects on body composition, glucose tolerance and insulin resistance in rat offspring. Exp. Physiol., 94: 761-769.
Direct Link - Shah, D. and H.P. Sachdev, 2001. Effect of gestational zinc deficiency on pregnancy outcomes: Summary of observation studies and zinc supplementation trials. Br. J. Nutr., 85: S101-S108.
CrossRefDirect Link - Salihoglu, O., G. Karatekin, B. Baksu, S. Uslu, A. Baksu, G. Can and A. Nuhoglu, 2012. Frequency and risk factors of fetal malnutrition among liveborn singleton term neonates using a computerised perinatal database, 2000-2006. J. Paediatr. Child Health, 48: 926-930.
CrossRefDirect Link - Tamura, T., R.L. Goldenberg, K.E. Johnston, S.P. Cliver and H.J. Hoffman, 1997. Serum concentrations of zinc, folate, vitamins A and E and proteins and their relationships to pregnancy outcome. Acta Obstet. Gynecol. Scand. Suppl., 165: 63-70.
PubMed - Ugwuja, E.I., E.I. Akubugwo, U.A. Ibiam and O. Obidoa, 2010. Impact of maternal copper and zinc status on pregnancy outcomes in a population of pregnant Nigerians. Pak. J. Nutr., 9: 678-682.
CrossRefDirect Link - Ugwuja, E.I., E.I. Akubugwo, U.A. Ibiam and O. Obidoa, 2011. Maternal sociodemographic parameters: Impact on trace element status and pregnancy outcomes in a population of pregnant Nigerians. J. Health Population Nutr., 29: 156-162.
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