Subscribe Now Subscribe Today
Abstract
Fulltext PDF
References
Research Article
 

The Relationship Between the Antioxidants Intake and Blood Indices of the Children with Thalassemia in Sabzevar and Mashhad



Akram Kooshki, Tahereh Towfighian, Fatemeh Rahnama Rahsepar and Arash Akaberi
 
ABSTRACT

Most of thalassemic patients have with deficiency of anti-oxidants and increase of oxidative stress and few studies have been performed on deficiency of vitamins A, E, C in these patients. In this research we intend to study the antioxidants intake and its relationship with anemia indices in children with thalassemia. This study is a retrospective study which was performed on the children with thalassemia in Sabzevar and Mashhad cities. The sampling method was target-based. In this study, 85 patients with thalassemia were examined. After taking written consent and filling the demographic questionnaire, their height and weight were measured through the common standard methods. Then, two questionnaires of two day meal reminder and meal frequency were completed for them (in order to determine the rate and pattern of receiving antioxidant in the present and the past) and 5cc of blood was taken from each of them so that the blood indices could be measured. The data gathered using statistical SPSS software and applying the correlation coefficient, linear regression, t test, Analysis of Variance (ANOVA) the relationships were analyzed. In this study 85 patients were studied, 48(56.5%) of whom were females and 37(43.5%) of them were males. The average age of them is 16.97±7.02 years-old and mean BMI of them was 19.03±3.71 kg/m2. The mean antioxidants received in these patients are vitamin A 883.35±1140.58 mcg, vitamin E 4.08±3.89 mg, vitamin C 204.40±238.71 mg and selenium 160±120 mcg, respectively. Among these antioxidants only vitamin C has a direct and significant correlation with hematocrit in the patients (p<0.05). In this study, between receiving vitamin A, MCV and MCH levels in the patients with thalassemia an inverse and significant relationship was observed.

Services
Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Akram Kooshki, Tahereh Towfighian, Fatemeh Rahnama Rahsepar and Arash Akaberi, 2010. The Relationship Between the Antioxidants Intake and Blood Indices of the Children with Thalassemia in Sabzevar and Mashhad. Pakistan Journal of Nutrition, 9: 716-719.

DOI: 10.3923/pjn.2010.716.719

URL: https://scialert.net/abstract/?doi=pjn.2010.716.719

REFERENCES
Aessopos, A., M. Katim and D. Farmakis, 2007. Heart disease in thalassemia intermedia: A review of the underlying pathophysiology. Haematologica, 92: 658-665.
CrossRef  |  

Ali, S., M.R. Nasr and E. El-Gabry, 2003. Malnutrition and growth abnormalities among egg patient. J. Food Sci., 31: 227-236.

Bazuaye, G.N., N.K. Halim and E. Olayemi, 2005. Megaloblastic anaemia: Response to Amples A and B (folic acid, vitamin B12 (Cyanocobalamin), niacin and vitamin C)-a case report. Niger. J. Med., 14: 442-446.
PubMed  |  

Cay, M. and M. Naziroglu, 1999. Effects of intra peritoneally-administered vitamin E and selenium on the blood biochemical and haematological parameters in rats. Cell Biochem. Funct., 17: 143-148.
PubMed  |  

Chen, K., J. Suh, A.C. Carr, J.D. Morrow, J. Zeind and B. Freid, 2000. Vitamin C suppresses oxidative lipid damage in vivo even in the presence of iron overload. Am. J. Physiol. Endocrionl. Metab., 279: 406-412.
Direct Link  |  

Cheng, M.L., H.Y. Ho, H.C. Tseng, C.H. Lee, L.Y. Shih and D.T. Chiu, 2005. Antioxidant deficit and enhanced susceptibility to oxidative damage in individuals with different forms of alpha-thalassemia. Br. J. Haematol., 128: 119-127.
PubMed  |  

Claster, S., J.C. Wood, L. Noetzli, S.M. Carson, T.C. Hofstra, R. Khanna and T.D. Coates, 2009. Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. Am. J. Hematol., 84: 344-348.
CrossRef  |  

Costa, M., 1986. Thalassemia, lipoperoxidation and antioxidant agent. Ganguly 1986.

Dhawan, V., K.R. Kumar, R.K. Marwaha and N.K. Ganguly, 2005. Antioxidant status in children with homozygous thalassemia. Pediatr., 42: 1141-1145.
PubMed  |  

Dissagabutra, T., P. Tosukhowong and P. Seksan, 2005. The benefits of vitamin C and vitamin E in children with β-thalassemia with high oxidative stress. J. Med. Assoc. Thai., 88: 317-321.
PubMed  |  

Gerster, H., 1999. High-dose vitamin C: A risk for persons with high iron stores? Int. J. Vitam Nutr. Res., 69: 67-82.
PubMed  |  

Katerelos, C., A. Constantopoulos, A. Agathopoulos, N. Constantzas, L. Zannos-Mariolea and N. Matsaniotis, 1979. Serum levels of retinol, retinol-binding protein, carotenoids and triglycerides in children with beta-thalassemia major. Acta Haematol., 62: 100-105.
PubMed  |  

Livrea, M.A., L. Tesoriere, A. Majjio, D. D'Arpa, A.M. Pintaudi and E. Pedone, 1998. Oxidative modification of low-density lipoprotein and atherogenic risk in β-thalassemia. Blood, 92: 3936-3942.
PubMed  |  

Livrea, M.A., L. Tesoriere, A.M. Pintaudi, A. Calabrese and A. Maggio et al., 1996. Oxidative stress and antioxidant status in β-thalassemia major: Iron overload and depletion of lipid-soluble antioxidants. Blood, 88: 3608-3614.
PubMed  |  Direct Link  |  

Ozdem, S., A. Kupesiz and A. Yesilipek, 2008. Plasma homocysteine levels in patients with beta-thalassemia major. Scand J. Clin. Lab. Invest., 68: 134-139.
PubMed  |  

Shenasi, H., M. Zamani and Jalal, 1997. Thalassemia, Vice Chancellor's Office for Research of Fars School of Medical Sciences in collaboration with Koush. 1st Edn., Mehr Publications, UK., pp: 1-2.

Tesoriere, L., M. Allegra, D. Butera, C. Gentile and M.A. Livrea, 2006. Cytoprotective effects of the antionidant phytochemical indicaxanthin in beta-thalassemia red blood cells. Free Radic. Res., 40: 753-761.
PubMed  |  

©  2019 Science Alert. All Rights Reserved
Fulltext PDF References Abstract