Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats

Research Article

**Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats**

Povi Lawson-Evi, Kwashie Eklu-Gadegbeku, Amegnona Agbonon, Kodjo Aklikokou, Edmond Creppy and Messanvi Gbeassor

This study was undertaken to investigate the antidiabetic effect of aqueous and hydroalcoholic extract of Phyllanthus amarus Schum and Thonn, a medicinal plant used in Togo for treatingdiabetes and many others diseases. Diabetes was induced in fasted rats (12 h) by a single intraperitoneal injection of 120 mg kg^-1 of alloxan monohydrate. Two doses (500 and 1000 mg kg^-1) of the both extracts of Phyllanthus amarus were administered orally to diabetic rats. The normal control group receives distilled water only. After 15 days treatment, body weight gain, blood glucose level, serum insulin, total cholesterol, triglycerides and malondialdehyde were evaluated. At the doses tested, aqueous and hydroalcoholic extract of P. amarus decrease significantly blood glucose level after 15 days of administration. Aqueous extract reduce body weight gain contrary to hydroalcoholic extract. Serum insulin increases in group treated with extracts in compared to diabetic control group. The hydroalcoholic extract reduce the malondialdehyde concentration in the serum. Values of total cholesterol and triglycerides are similar in all the groups. This study demonstrated the potential antidiabetic property of aqueous and hydroalcoholic extract of Phyllanyhus amarus thus justifying its traditional usage.

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Povi Lawson-Evi, Kwashie Eklu-Gadegbeku, Amegnona Agbonon, Kodjo Aklikokou, Edmond Creppy and Messanvi Gbeassor, 2011. Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats. Journal of Applied Sciences, 11: 2968-2973.

DOI: 10.3923/jas.2011.2968.2973

URL: https://scialert.net/abstract/?doi=jas.2011.2968.2973

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Povi Lawson-Evi

Kwashie Eklu-Gadegbeku

Amegnona Agbonon

Kodjo Aklikokou

Edmond Creppy

Messanvi Gbeassor

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Research Article

**Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats**

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