• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Journal of Applied Sciences
  2. Vol 11 (16), 2011
  3. 2968-2973
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Journal of Applied Sciences

Year: 2011 | Volume: 11 | Issue: 16 | Page No.: 2968-2973
DOI: 10.3923/jas.2011.2968.2973

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 387

Authors


Povi Lawson-Evi


Kwashie Eklu-Gadegbeku


Amegnona Agbonon


Kodjo Aklikokou

Country: France

Edmond Creppy

Country: France

Messanvi Gbeassor


Keywords


  • antidiabetic
  • alloxan
  • Phyllanthus amarus
  • antioxidant
Research Article

Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats

Povi Lawson-Evi, Kwashie Eklu-Gadegbeku, Amegnona Agbonon, Kodjo Aklikokou, Edmond Creppy and Messanvi Gbeassor
This study was undertaken to investigate the antidiabetic effect of aqueous and hydroalcoholic extract of Phyllanthus amarus Schum and Thonn, a medicinal plant used in Togo for treatingdiabetes and many others diseases. Diabetes was induced in fasted rats (12 h) by a single intraperitoneal injection of 120 mg kg-1 of alloxan monohydrate. Two doses (500 and 1000 mg kg-1) of the both extracts of Phyllanthus amarus were administered orally to diabetic rats. The normal control group receives distilled water only. After 15 days treatment, body weight gain, blood glucose level, serum insulin, total cholesterol, triglycerides and malondialdehyde were evaluated. At the doses tested, aqueous and hydroalcoholic extract of P. amarus decrease significantly blood glucose level after 15 days of administration. Aqueous extract reduce body weight gain contrary to hydroalcoholic extract. Serum insulin increases in group treated with extracts in compared to diabetic control group. The hydroalcoholic extract reduce the malondialdehyde concentration in the serum. Values of total cholesterol and triglycerides are similar in all the groups. This study demonstrated the potential antidiabetic property of aqueous and hydroalcoholic extract of Phyllanyhus amarus thus justifying its traditional usage.
PDF Fulltext XML References Citation

How to cite this article

Povi Lawson-Evi, Kwashie Eklu-Gadegbeku, Amegnona Agbonon, Kodjo Aklikokou, Edmond Creppy and Messanvi Gbeassor, 2011. Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats. Journal of Applied Sciences, 11: 2968-2973.

DOI: 10.3923/jas.2011.2968.2973

URL: https://scialert.net/abstract/?doi=jas.2011.2968.2973

Related Articles

Study of the Inhibition of Deoxyhemoglobin S Polymerization by the Hydroalcoholic Extract of Morinda lucida
Pharmacological Effects of Pimpinella tirupatiensis on Altered Urea Cycle and Liver Function Markers in Diabetic Rats
HPTLC and HPLC Analysis of Bioactive Phyllanthin from Different Organs of Phyllanthus amarus
Increase Insulin Activity by Phyllanthus amarus Linn on Liver Cell Regeneration in Partially Hepatectomised Albino Rats
Liver Regenerative Effect of Phyllanthus amarus Linn. Against Alcohol Induced Liver Cell Injury in Partially Hepatectomised Albino Rats
Alloxan-Induced Diabetes in Rats and the Effects of Black Caraway (Carum carvi L.) Oil on Their Body Weights
An Overview: Pharmacognostic Properties of Phyllanthus amarus Linn.

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved