Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Applied Sciences
  Year: 2011 | Volume: 11 | Issue: 16 | Page No.: 2968-2973
DOI: 10.3923/jas.2011.2968.2973
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats
Povi Lawson-Evi, Kwashie Eklu-Gadegbeku, Amegnona Agbonon, Kodjo Aklikokou, Edmond Creppy and Messanvi Gbeassor

Abstract:
This study was undertaken to investigate the antidiabetic effect of aqueous and hydroalcoholic extract of Phyllanthus amarus Schum and Thonn, a medicinal plant used in Togo for treatingdiabetes and many others diseases. Diabetes was induced in fasted rats (12 h) by a single intraperitoneal injection of 120 mg kg-1 of alloxan monohydrate. Two doses (500 and 1000 mg kg-1) of the both extracts of Phyllanthus amarus were administered orally to diabetic rats. The normal control group receives distilled water only. After 15 days treatment, body weight gain, blood glucose level, serum insulin, total cholesterol, triglycerides and malondialdehyde were evaluated. At the doses tested, aqueous and hydroalcoholic extract of P. amarus decrease significantly blood glucose level after 15 days of administration. Aqueous extract reduce body weight gain contrary to hydroalcoholic extract. Serum insulin increases in group treated with extracts in compared to diabetic control group. The hydroalcoholic extract reduce the malondialdehyde concentration in the serum. Values of total cholesterol and triglycerides are similar in all the groups. This study demonstrated the potential antidiabetic property of aqueous and hydroalcoholic extract of Phyllanyhus amarus thus justifying its traditional usage.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Study of the Inhibition of Deoxyhemoglobin S Polymerization by the Hydroalcoholic Extract of Morinda lucida
  •    Pharmacological Effects of Pimpinella tirupatiensis on Altered Urea Cycle and Liver Function Markers in Diabetic Rats
  •    HPTLC and HPLC Analysis of Bioactive Phyllanthin from Different Organs of Phyllanthus amarus
  •    Increase Insulin Activity by Phyllanthus amarus Linn on Liver Cell Regeneration in Partially Hepatectomised Albino Rats
  •    Liver Regenerative Effect of Phyllanthus amarus Linn. Against Alcohol Induced Liver Cell Injury in Partially Hepatectomised Albino Rats
  •    Alloxan-Induced Diabetes in Rats and the Effects of Black Caraway (Carum carvi L.) Oil on Their Body Weights
How to cite this article:

Povi Lawson-Evi, Kwashie Eklu-Gadegbeku, Amegnona Agbonon, Kodjo Aklikokou, Edmond Creppy and Messanvi Gbeassor, 2011. Antidiabetic Activity of Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats. Journal of Applied Sciences, 11: 2968-2973.

DOI: 10.3923/jas.2011.2968.2973

URL: https://scialert.net/abstract/?doi=jas.2011.2968.2973

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom