Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2011.2968.2973Phyllanthus amarus Schum and Thonn (Euphorbiaceae) on Alloxan Induced Diabetes in Male Wistar Rats]]>EviPovi LawsonGadegbekuKwashie EkluAgbononAmegnona AklikokouKodjo CreppyEdmond GbeassorMessanvi 1220111116This study was undertaken to investigate the antidiabetic effect of aqueous and hydroalcoholic extract of Phyllanthus amarus Schum and Thonn, a medicinal plant used in Togo for treatingdiabetes and many others diseases. Diabetes was induced in fasted rats (12 h) by a single intraperitoneal injection of 120 mg kg-1 of alloxan monohydrate. Two doses (500 and 1000 mg kg-1) of the both extracts of Phyllanthus amarus were administered orally to diabetic rats. The normal control group receives distilled water only. After 15 days treatment, body weight gain, blood glucose level, serum insulin, total cholesterol, triglycerides and malondialdehyde were evaluated. At the doses tested, aqueous and hydroalcoholic extract of P. amarus decrease significantly blood glucose level after 15 days of administration. Aqueous extract reduce body weight gain contrary to hydroalcoholic extract. Serum insulin increases in group treated with extracts in compared to diabetic control group. The hydroalcoholic extract reduce the malondialdehyde concentration in the serum. Values of total cholesterol and triglycerides are similar in all the groups. This study demonstrated the potential antidiabetic property of aqueous and hydroalcoholic extract of Phyllanyhus amarus thus justifying its traditional usage.]]>Adeneye, A.A., O.O. Amole and A.K. Adeneye,2006Phyllanthus amarus in mice.]]>77511514Annamalai, A. and P.T.V. Lakshmi,2009Phyllanthus amarus.]]>1154162Boquist, L., L. Nelson and R. Lorentzon,1983in vivo and in vitro.]]>113943948Butler, L.G.,199259693698Carbonaro, M., G. Grant and A. Pusztai,2001408490Chattopadhyay, P., A. Garg, V.P. Varshey, A.K. Sharma and S.S. Agrawal,2007Phyllanthus amarus linn on liver cell regeneration in partially hepatectomised albino rats.]]>11720Chattopadhyay, P., S.S. Agrawal and A. Garg,2006Phyllanthus amarus Linn. against alcohol induced liver cell injury in partially hepatectomised albino rats.]]>2426430Ene, A.C., E.A. Nwankwo and L.M. Samdi,2008Carum carvi L.) oil on their body weights.]]>3141146Huang, R.L., Y.L. Huang, J.C. Ou, C.C. Chen, F.L. Hsu and C. Chang,2003Phyllanthus species for anti-human hepatitis B virus in vitro.]]>17449453IDF,20032003Janjic, D., P. Maechler, N. Sekine, C. Bartley, A.S. Annen and C.B. Wollheim,199957639648Joseph, B. and S.J. Raj,2011Phyllanthus amarus Linn.]]>74045Kassuya, C.A.L., A. Silvestre, J.O. Menezes-de-Lima, D.M. Marottaa, V.L.G. Rehder and J.B. Calixto,2006Phyllanthus amarus: Evidence for interaction with platelet activating factor receptor.]]>546182188Kiemer, A.K., T. Hartung, C. Huber and A.M. Vollmer,2003Phyllanthus amarus has anti-inflammatory potential by inos, COX-2 and cytokines via the NF-kappa B Pathway.]]>38289297Kumaran, A. and R.J. Karunakaran,2007In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India.]]>40344352Lawson-Evi, P., K. Eklu-Gadegbeku, A. Agbonon, K. Aklikokou, S. Moukha, E.E. Creppy and M. Gbeassor,2008Phyllanthus amarus Schum and Thonn.]]>3410415Notka, F., G.R. Meier and R. Wagner,2003Phyllanthus amarus.]]>58175186Oliveira, A.C.P., D.C. Endringer, L.A.S. Amorim, M. das Gracas, M.G.L. Brandao and M.M. Coelho,2005Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice.]]>102465469Proks, P., F. Reimann, N. Green, F. Gribble and F. Ashcroft,200251S368S376Raphael, K.R., M.C. Sabu and R. Kuttan,2002Phyllanthus amarus schum and thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential.]]>40905909Sekiya, N., Y. Shimada, N. Shibahara, S. Takagi and K. Yokoyama et al.,2002Uncariasinensison free radical-induced lysis of rat red blood cells.]]>9636640Shokunbi, O. and A. Odetola,2008Phyllanthusamarus extracts on absolute ethanol induced ulcer in albino rats.]]>2261267Takasawa, S. and H. Okamoto,200237996Weaver, D.C., M.L. McDaniel and P.E. Lacy,197810218471855Wiernsperger, N.F.,200329579585Yeh, G.Y., D.M. Eisenberg, T.J. Kaptchuk and R.S. Phillips,20032612771294Lawson-Evi, P., K. Eklu-Gadegbeku, A.K. Aklikokou, K. Akpagana, K. Koumaglo and M. Gbeassor,199796069