Submit Manuscript

Research Journal of Phytochemistry

Year: 2011 | Volume: 5 | Issue: 2 | Page No.: 123-129
Research Article

A Preclinical Study on Wound Healing Activity of Lawsonia ulba Linn.

V. Nithya
Department of Biotechnology, Srimad Andavan Arts and Science College, Tiruchirappalli 620003, Tamil Nadu, India
Anusha Baskar
Dhanalakshmi Srinivasan College for Women, Perambalur 621212, Tamil Nadu, India
Lawsonia ulba Linn., is a reputed medicinal plant used in the treatment of various skin diseases in the Indian system of medicine. The objective of the study presented in this article was to evaluate the wound-healing potential of the ethanolic extract. The study was done on Wistar albino rats using excision, and dead space wounds models. The extract of Lawsonia ulba Linn., treated wounds were found to epithelize faster and the rate of wound contraction was significantly increased as compared to control wounds (p<0.01). Wet and dry granulation tissue weights and granulation tissue tensil strength in a dead space wound model also increased at statistically Significant differences at p<0.001 when compared to control. From the results, it may be concluded that, the ethanolic extract of Lawsonia ulba Linn. had greater wound healing activity than the nitrofurazone ointment.
PDF Fulltext XML References Citation

Related Articles

Antioxidant and Analgesic Activities of Lannea coromandelica Linn. Bark Extract
Preliminary Study on Polysaccharides and Certain Secondary Metabolites of Medicinal Plants used in Cote D’Ivoire for Wound Healing
Evaluation of Antioxidant, Anti-inflammatory and Analgesic Potential of the Luffa acutangula Roxb. Var. amara
Experimental Evaluation of Repair Process of Burn-Wounds Treated with 15 UMF Manuka Honey
Pharmacological and Toxicological Properties of Leaf Extracts of Kingelia africana (Bignoniaceae)
The Efficacy of Aqueous Extract of Iranian Garlic on the Healing of Burn Wound: A Clinical and Microbiological Study
Plectranthus tenuiflorus (Shara) Promotes Wound Healing: In vitro and in vivo Studies
Role of Medicinal Plants in Wound Healing

Comments

arun Reply

your article is so good. can you send me the plant details.

Raju Gopinath Reply

I have seen your article about wound healing activity of lawsonia ulba linn., in science alert journals. It is so better and very useful for my research work. Can you give some ideas about publications through my email.
Thank You

Leave a Comment

Your email address will not be published. Required fields are marked *

Article Trend

Total views 4737

References

  1. Anonymous, 1993. British Pharmacopoeia. Vol. II, HMSO, London.
  2. Barbul, A., G. Rettura, S.M. Levenson and E. Seifter, 1983. Wound healing and thymotropic effects of arginine: A pituitary mechanism of action. Am. J. Chin. Nutr., 37: 786-794.
    PubMed
  3. Bosoglu, A., F. Birdane and H., Solmaz, 1998. The effect of Lawsonia ulbaLlinn., (Folium lawsoniae) paste in ringworm in calves. Indian Vet. J., 75: 83-84.
  4. Chetty, K.M., 2008. Flowering Plants of Chittoor. 1st Edn., Andhra Pradesh, India, pp: 132.
  5. MacKay, D.J and A.l. Miller, 2003. Nutritional support for wound healing. Alternative Med. Rev., 8: 359-377.
    Direct Link
  6. Guillaume, M. and F. Padioleau, 1994. Veinotonic effect, vascular protection, anti-inflammatory and free radical scavenging properties of horse chestnut extract. Arzneimittelforschung, 44: 25-35.
    PubMedDirect Link
  7. Kay, M.A., 1996. Healing with Plants in the American and Mexican West. University of Arizon Press, Tucson, pp: 178-181.
  8. Lee, K.H., 1968. Studies on the mechanism of action of salicylate II. Retardation of wound healing by aspirin. J. Pharmaceu. Sci., 57: 1042-1043.
    CrossRefDirect Link
  9. Morton, J.J. and M.H. Malone, 1972. Evaluation of vulneray activity by an open wound procedure in rats. Arch. Int. Pharmacodyn. Ther., 196: 117-126.
    PubMed
  10. Nasemann, T., 1975. Kamillosan7 therapy in dermatology. Z. Allg. Med., 25: 1105-1106.
  11. Nayak, B.S., 2006. Cecropial Peltata (Cecropiaceae) has wound healing potential-A preclinical study in sprague dawley rat model. Int. J. lower Extremity Wounds, 5: 20-26.
    CrossRef
  12. Nithya, V., 2011. Phytochemical studies of Lawsonia ulba Linn. a medicinal plant. Inventi Rapid Ethnopharmacol., Vol. 2, Issue No. 1.
  13. Parthiban, K., S. Manikandan and S. Ganesapandian, 2011. Production of cellulose I microfibrils from Rhizobium sp. and its wound healing activity on mice. Asian J. Appl. Sci., 4: 247-254.
    CrossRefDirect Link
  14. Patil, D.N., A.R. Kulkarni, A.A. Shahapurkar and B.C. Hatappakki, 2009. Natural cumin seeds for wound healing activity in albino rats. Int. J. Biol. Chem., 3: 148-152.
    CrossRefDirect Link
  15. Paul, W. and C.P. Sharma, 2004. Chitosan and alginate wound dressings: A short review. Trends Biomater. Artif. Organs, 18: 18-23.
    Direct Link
  16. Singh, S., N.M. Shrivastava, N.T. Modi and A.Q. Saifi, 1982. Anti-inflammatory activity of Lawsonia inermis. Curr. Sci., 51: 470-471.
    Direct Link
  17. Vogel, S., 1971. Practical Organic Chemistry. E.L.B.S. London.
  18. Lazarus, G.S., D.M. Cooper, D.R. Knighton, D.J. Margolis, R.E. Pecoraro, G. Rodeheaver and M.C. Robson, 1994. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch. Dermatol., 130: 489-493.
    Direct Link
  19. Muhammad, H.S. and S. Muhammad, 2005. The use of Lawsonia inermis linn. (henna) in the management of burn wound infections. Afr. J. Biotechnol., 4: 934-937.
    Direct Link
  20. Natarajan, V., P.V. Venugopal and T. Menon, 2003. Effect of Azadirachta indica (neem) on the growth pattern of dermatophytes. Indian J. Med. Microbiol., 21: 98-101.
    PubMedDirect Link
  21. Forest, R.D., 1982. Development of wound therapy from the dark ages to the present. J. R. Soc. Med., 75: 268-273.
    Direct Link
  22. Khorshid, F., S.S. Ali, T. Alsofyani and H. Albar, 2010. Plectranthus tenuiflorus (Shara) promotes wound healing: In vitro and in vivo studies. Int. J. Bot., 6: 69-80.
    CrossRefDirect Link
  23. Puratchikody, A. and G. Nagalakshmi, 2007. Wound healing activity of Memecylon umbellatum burm. J. Plant Sci., 2: 179-186.
    CrossRefDirect Link
  24. Nagori, B.P. and R. Solanki, 2011. Role of medicinal plants in wound healing. Res. J. Med. Plant, 5: 392-405.
    CrossRefDirect Link
  25. Jalali, F.S.S., S. Saifzadeh, H. Tajik and S. Hobbi, 2008. The efficacy of aqueous extract of Iranian garlic on the healing of burn wound: A clinical and microbiological study. Asian J. Anim. Vet. Adv., 3: 162-168.
    CrossRefDirect Link
  26. Fei, Y.M., A.G. Pillay and J. Zainol, 2003. Experimental evaluation of repair process of burn-wounds treated with 15 UMF manuka honey. J. Medical Sci., 3: 358-366.
    CrossRefDirect Link
  27. Hassan, S.W., M.G. Abubakar, R.A. Umar, A.S. Yakubu, H.M. Maishanu and G. Ayeni, 2011. Pharmacological and toxicological properties of leaf extracts of Kingelia africana (bignoniaceae). J. Pharmacol. Toxicol., 6: 124-132.
    CrossRefDirect Link
  28. Pattanayak, S.P. and P. Sunita, 2008. Wound healing, anti-microbial and antioxidant potential of Dendrophthoe falcate (L.f) Ettingsh. J. Ethnopharmacol., 120: 241-247.
    Direct Link
  29. Suguna, P., L. Sivakumar and C. Gowri, 1996. Effects of cen-tella asitica extract on dermal wound healing in rats. Indian J. Exp. Biol., 34: 1208-1211.
    PubMed
  30. Nayak, B.S., B. Vinutha, B. Geetha and B. Sudha, 2005. Experimental evaluation of Pentas lanceolata flowers for wound healing activity in rats. Fitoterapia, 76: 671-675.
    CrossRef

Keywords