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Journal of Medical Sciences

Year: 2003 | Volume: 3 | Issue: 5 | Page No.: 358-366
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Authors

Yam Mun Fei

A.G. Pillay

Jamaludin Zainol

Keywords

Research Article

Experimental Evaluation of Repair Process of Burn-Wounds Treated with 15 UMF Manuka Honey

Yam Mun Fei, A.G. Pillay and Jamaludin Zainol
In this experiment, 30 laboratory albino rats were tested to compare the effectiveness of 15 UMF manuka honey in the treatment of burn wounds in contrast to the control group for wounds= tensile strength and histopathological changes during healing process. The treatments were applied on the deep partial thickness burn wounds inflicted by modified electric solder (Yam Mun Fei, 2002). Three rats from each group were studied at day 5, day 10, day 15 and day 20 for histopathological and tensile strength studies. Three rats were randomly selected from each group (treatment and control groups) within 24 hours (day 0) post burned to determine histological changes. Generally, the tensile strength increased on day 5 and day 10 because of fibroblast activity (Kenyon and Michaels, 1983) and decreased on day 15 and day 20 due to the rearrangement of the collagen (Lee et al., 1986). However, there is no significant difference (P<0.05) in the tensile strengths of both the treatment and control groups on various days. The treatment group healed faster compared to the control group. The 15 UMF manuka honey treatment showed scar formation after 6 to 9 days post burned and the control showed scarring after 8-12 days. However, all the wounds didn’t show any sign of infection and no pustule was observed during the experimental period. Epithelialization was observed in the 15 UMF manuka honey treatment on day 5 and almost completed by day 10, whereas the control group showed complete epithelialization only on day 15 and day 20.
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