Effects of Sustanon on the Distribution of Satellite Cells and The Morphology of Skeletal Muscle Fibers During Maturation


	Pakistan Journal of Biological Sciences
	Year: 2012 \| Volume: 15 \| Issue: 5 \| Page No.: 215-223 DOI: 10.3923/pjbs.2012.215.223

Effects of Sustanon on the Distribution of Satellite Cells and The Morphology of Skeletal Muscle Fibers During Maturation

Mohammed Z. Allouh and Mohammed H. Aldirawi

Abstract: Sustanon is one of the most commonly used anabolic androgenic drugs to increase skeletal muscle mass and strength. This drug is a blend of four esterized testosterone derivatives: Testosterone propionate, testosterone phenylpropionate, testosterone isocaproate and testosterone decanoate. Little is known about the effects of this drug on skeletal muscle at the cellular level. This study aimed to investigate the influence of Sustanon on the morphology of skeletal muscle fibers and the distribution of myogenic stem cells known as Satellite Cells (SCs) during postnatal growth. We hypothesized that Sustanon-induced skeletal muscle hypertrophy is associated with an increase in the number of SCs. Robust immunocytochemical techniques and morphometric analyses were used to calculate the numbers of SCs and myonuclei within the pectoralis muscle of chickens. Also, DNA concentration and Pax7 protein levels were measured to confirm immunocytochemical findings. Sustanon significantly increased pectoralis mass and fiber size. All SC indices and the number of myonuclei increased significantly by Sustanon administration. In addition, greater DNA concentration and Pax7 protein expression were found in Sustanon-treated birds. This study indicates that Sustanon can induce avian skeletal muscle hypertrophy and that this is correlated with increased numbers of SCs and myonuclei.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Myogenic Satellite Cells: Biological Milieu and Possible Clinical Applications

•	Histopathological Evidences of the Nephritic PathologicalAlterationsInduced by the Anabolic Androgenic Drug (Sustanon) in Male Guinea Pigs (Cavia porcellus)

•	Antioxidant Effect of ECG on Testosterone Propionate Induced Chromosome Damage

•	Anabolic Steroid Exposure of Athletes of Qom, Iran, Through Performance Enhancing Drugs Use

•	Influence of 17-Alpha Methyl Testosterone on Masculinization and Growth in Tilapia (Oreochromis mossambicus)

How to cite this article:

Mohammed Z. Allouh and Mohammed H. Aldirawi, 2012. Effects of Sustanon on the Distribution of Satellite Cells and The Morphology of Skeletal Muscle Fibers During Maturation. Pakistan Journal of Biological Sciences, 15: 215-223.

DOI: 10.3923/pjbs.2012.215.223

URL: https://scialert.net/abstract/?doi=pjbs.2012.215.223

COMMENTS

30 August, 2013
cheap steroids uk:
I bought testosterone boosters to help my muscles, increase my energy, and metabolism how do i block estrogen?

REPLY

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI

Follow @scialert

Science Alert