
	Journal of Biological Sciences
	Year: 2009 \| Volume: 9 \| Issue: 6 \| Page No.: 514-523 DOI: 10.3923/jbs.2009.514.523

Histopathological Evidences of the Nephritic PathologicalAlterationsInduced by the Anabolic Androgenic Drug (Sustanon) in Male Guinea Pigs (Cavia porcellus)

A.S. Ahmed Bin Bisher

Abstract: The present histopathological study on male guinea pigs aims to investigate the potential histopathological alterations and damages in the kidneys structure induced by the repeated administration of two doses of Sustanon drug. The treated animals in this study were injected once every week with two Sustanon doses as follow (15 mg kg^-1 in group GII and 30 mg kg^-1 in group GIII) for a continuous treatment period of 6 weeks. The histopathological examination of the of kidneys cross sections of the treated animals in group (GIII) showed multiple abnormal alterations and damages in the kidneys in the following forms glomeruli atrophy and glomeruli fragmentation accompanied with dilatation of the urinary spaces, abnormal vasodilatation of blood vessels, irregular dilatations of the proximal and distal convoluted tubules associated with degeneration of epithelial cells in the tubules lumens. Furthermore, the worst histopathological damages induced by Sustanon doses appeared in the form of massive and intensive blood hemorrhage in different places of the nephritic tissues, severe rupture of walls of the proximal and distal convoluted tubules and wide abnormal lacerations inside the nephritic tissues. These results may prove that abusing high doses of Sustanon for long periods by athletes can cause severe histopathological damages in the kidneys structure. One of important points which can be concluded from the current results is that physicians should take renal disorders in mind seriously as one of the predictable complications resulting from abusing these drugs such as Sustanon. Finally, the present study recommends that athletes and youths should be supplied with much more medical enlightenment about the health risks and the complications which resulted from abusing these drugs through media.

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How to cite this article:

A.S. Ahmed Bin Bisher , 2009. Histopathological Evidences of the Nephritic PathologicalAlterationsInduced by the Anabolic Androgenic Drug (Sustanon) in Male Guinea Pigs (Cavia porcellus). Journal of Biological Sciences, 9: 514-523.

DOI: 10.3923/jbs.2009.514.523

URL: https://scialert.net/abstract/?doi=jbs.2009.514.523

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