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International Journal of Pharmacology

Year: 2021 | Volume: 17 | Issue: 7 | Page No.: 442-454
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Authors

Yang Kui

Ding Yanyun

Jin Wan

Wang Yaqin

Chen Lu

Zhang Wen

Wang Wusan

Ma Zhangqing

Luan Jiajie

Luan Jiajie

Keywords

Background and Objective: Researches have reported that valsartan or melatonin bedtime administration showed a positive therapy to treat non-dipping Blood Pressure (BP), respectively. However, the combined effect of these two drugs in the treatment of non-dipping BP is unknown. Thus, this work aimed to evaluate the combined effects of valsartan and melatonin in the treatment of Spontaneous Hypertension Rats (SHR) with non-dipping BP and to explore its potential mechanism. Materials and Methods: A total of 28 male Wistar-Kyoto rats (WKY) was utilized as a non-disease control. A total of 144 male SHRs were treated with valsartan (10 mg/kg/day) combined with or without melatonin (20 mg/kg/day) after light onset. The 24 hrs BP, ANG II, ET-1, NO, Per1 and Per2 mRNA levels were detected. Nonlinear regression was used to calculate parameters of circadian BP rhythm. Inter-group means were compared using a One-Way Analysis Of Variance (ANOVA). Results: Valsartan administration with or without melatonin can significantly reduce active BP, restored circadian BP rhythm. Moreover, combination therapy reduced plasma levels of ANG II, ET-1 and NO, restored circadian rhythm ANG II in SHR rats and down-regulated the expression of Per1 mRNA in the aorta abdominalis. Conclusion: Melatonin combined with valsartan significantly reduced BP and restored circadian BP rhythm than a single drug. The mechanism may associates with decreased Per genes expression and recover circadian rhythm of plasma ANG II.
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How to cite this article

Yang Kui, Ding Yanyun, Jin Wan, Wang Yaqin, Chen Lu, Zhang Wen, Wang Wusan, Ma Zhangqing and Luan Jiajie, 2021. Combination of Valsartan and Melatonin to Treat Non-Dipping Hypertension Rats via Circadian Clock System. International Journal of Pharmacology, 17: 442-454.

DOI: 10.3923/ijp.2021.442.454

URL: https://scialert.net/abstract/?doi=ijp.2021.442.454

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