Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 4 | Page No.: 546-552
DOI: 10.3923/ijp.2018.546.552
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Anti-angiogenic and Antioxidant Activity of Iraqi Cyperus rotundus Ethanol Extract
Amjed Haseeb Khamees, Ali Jabbar Abdulhussein, Hayder Bahaa Sahib and Hayder Adnan Fawzi

Abstract: Background and Objective: Cyperus rotundus (C. rotundus) has been used in medicine years ago. The aim of the study was to investigate the possible anti-angiogenic and antioxidant activity and to find the different phytochemicals present in Cyperus rotundus ethanol extract that may has anti-angiogenic activity. Methodology: Qualitative analysis of various secondary metabolites by specific chemical tests was carried out on the ethanol extract. The ex vivo rat aorta ring assay was used to screen the extract for possible anti-angiogenic activity, this assay was also used to determine the dose-response effect of the active extract. Six concentrations of crude extract were tested (100, 50, 25, 12.5, 6.25 and 3.125 μg mL–1) on rat aortic rings to determine the dose response curve. Free radical scavenging activity of extract was determined by 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) assay. Results: Cyperus rotundus ethanol extract showed significant dose-dependent blood vessels inhibition in comparison to the negative control (p<0.05). Ethanol extract showed significant free radical scavenging activity. Phytochemical investigation of alcoholic extract indicated the presence of various chemical constituents like alkaloids, glycosides, steroids, tannins, carbohydrates and flavonoids. Conclusion: The anti- angiogenic activity showed by the ethanol extract may be due to the presence of antioxidant compounds.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Anti-Angiogenic and Anti Oxidant Properties of Orthosiphon stamineus Benth. Methanolic Leaves Extract
  •    The Role of Medicinal Herbs in Angiogenesis Related Diseases
How to cite this article:

Amjed Haseeb Khamees, Ali Jabbar Abdulhussein, Hayder Bahaa Sahib and Hayder Adnan Fawzi, 2018. Anti-angiogenic and Antioxidant Activity of Iraqi Cyperus rotundus Ethanol Extract. International Journal of Pharmacology, 14: 546-552.

DOI: 10.3923/ijp.2018.546.552

URL: https://scialert.net/abstract/?doi=ijp.2018.546.552
COMMENT ON THIS PAPER
 
 
 

 
  Bullet Navigation
 
  Page Icon Online First
  Page Icon Current Issue
  Page Icon Previous Issues
  Page Icon Editorial Board
  Page Icon Submit a Manuscript
  Page Icon Guide to Authors
  Page Icon Subscribe to E-alerts

  Bullet Indexed In
 
  Page Icon ASCI-Database
  Page Icon Asian Digital Library
  Page Icon Chemical Abstract Services
  Page Icon EMBASE
  Page Icon Google Scholar
  Page Icon ISI Web of Knowledge
  Page Icon Science Citation Index (EXP)
  Page Icon SCIMAGO
  Page Icon Thomson ISI

Science Alert
Curve Bottom