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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 5 | Page No.: 696-704
DOI: 10.3923/ijp.2010.696.704
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Studies of CNS Activities of Some Mannich bases of 1,3,4-Oxadiazole

R.R. Somani, G. Kadam, R. Vohra, S. Vijayaraghavan and P.Y. Shirodkar

The present study demonstrated the various Central Nervous System effects like depressant, sedative-hypnotic, anticonvulsant and anxiolytic activities of some Mannich bases of 2,5-disubstituted-1,3,4-oxadiazole on albino mice. Before their evaluation for Central Nervous System activities, these derivatives were subjected to preliminary screening for anticonvulsant activity and toxicity studies concluding that the compounds are non toxic and Central Nervous System depressant in nature. Various animal models were utilized, such as, for depressant activity: ambulatory activity, Hole-board and Rotarod; for sedative-hypnotic activity: Ketamine-induced sleeping time; for anticonvulsant activity: Maximum Electroshock, Pentylene tetrazole induced convulsions and Strychnine induced convulsions; for anxiolytic activity: Staircase test, Elevated Plus Maze model. It was found that the test compounds of doses 50, 100 and 150 mg kg-1, showed significant dose dependent increase in the above Central Nervous System activities when administered intra peritoneally.
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How to cite this article:

R.R. Somani, G. Kadam, R. Vohra, S. Vijayaraghavan and P.Y. Shirodkar, 2010. Studies of CNS Activities of Some Mannich bases of 1,3,4-Oxadiazole. International Journal of Pharmacology, 6: 696-704.

DOI: 10.3923/ijp.2010.696.704






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