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Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 2 | Page No.: 64-77
DOI: 10.3923/jpt.2012.64.77
 
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Effect of Repeated Administration of Paeonia emodi Wall Root Extract in Experimental Models of Epilepsy and Behavior

S.M. Abbas Zaidi, Shadab Ahmad Pathan, Surender Singh, F.J. Ahmad, S.S. Jamil and R.K. Khar

Abstract:
The root of Paeonia emodi wall has been used for thousands of years to treat epilepsy in Unani medicine. This study aimed to investigate the reported antiepileptic, neuroprotective and anxiolytic activities of Paeonia emodi root in Unani literature. Paeonia emodi root ethanolic extract (PEE) (300 and 600 mg kg-1) per orally was evaluated on Pentylenetetrazole (PTZ) kindling seizures in mice and was tested for its ability (1) to suppress the convulsive and lethal effects of PTZ in kindled mice (anti-epileptogenic effect) (2) to attenuate the PTZ-induced oxidative injury in the brain tissue (antioxidant effect). Besides, PEE was also evaluated to test its ability to prevent PTZ induced memory impairment using Morris water maze test, anxiolytic potential by examining the animal’s performance on elevated plus maze test and to rule out any associated motor impairment of the test drug by using grip strength and Rotarod performance tests. ANOVA followed by Dunnett’s test was used to evaluate the results along with Kruskall Wallis analysis by ranks was performed for evaluating kindling comparison. PEE significantly decreased oxidative injury in the mouse brain tissue in comparison with the PTZ-kindling group, however, PEE 600 mg kg-1 was found to be the most effective in preventing PTZ-induced seizures relative to valproate. Besides showing antiepileptogenic potential, PEE also exhibited statistically significant anxiolytic, antioxidant activity without any evidence of causing any cognitive or motor impairment. The findings suggest the potential of PEE as adjuvant to antiepileptic drugs with an added advantage of preventing cognitive impairment.
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How to cite this article:

S.M. Abbas Zaidi, Shadab Ahmad Pathan, Surender Singh, F.J. Ahmad, S.S. Jamil and R.K. Khar, 2012. Effect of Repeated Administration of Paeonia emodi Wall Root Extract in Experimental Models of Epilepsy and Behavior. Journal of Pharmacology and Toxicology, 7: 64-77.

DOI: 10.3923/jpt.2012.64.77

URL: https://scialert.net/abstract/?doi=jpt.2012.64.77

COMMENTS
08 March, 2012
Sanjay Baveja:
It is very informative paper covering so many aspects of a medicinal herb on which there is very little published data available.
03 November, 2013
Faizan Khan:
Good and very informative paper on this important medicinal herb native to pakistan.
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