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International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 309-315
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Authors

A.A. Alhaider

I.A. Al-Mofleh

J.S. Mossa

M.O. Al-Sohaibani

S. Rafatullah

S. Qureshi

Keywords

The effect of Carum carvi L. pretreatment on gastric mucosal injuries caused by NaCl, NaOH, ethanol and pylorous ligation accumulated gastric acid secretions was investigated in rats. Pretreatment at oral doses of 250 and 500 mg kg-1, body weight was found to provide a dose-dependent protection against the (i) ulcerogenic effects of different necrotizing agents (ii) ethanol-induced histopathological lesions, depletion of stomach wall mucus and Nonprotein Sulfhydryl groups (NP-SH) and (iii) pylorous ligated accumulation of gastric acid secretions. The protective effect of Carum carvi against ethanol-induced damage of the gastric tissue appears to be related with the free-radical scavenging property of its constituents. The exact mechanism of action of the gastroprotective activity is not known. However, it might be due to flavonoid related suppression of cytochrome P450 1A1 (CYP1A1) which are known to convert xenobiotics and endogenous compounds to toxic metabolites.
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