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Research Journal of Medicinal Plants

Year: 2011 | Volume: 5 | Issue: 4 | Page No.: 477-490
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Authors

Atef M. Al-Attar

Keywords

Research Article

Protective Effect of Avicennia alba Leaves Extract on Gastric Mucosal Damage Induced by Ethanol

Atef M. Al-Attar
The present study was conducted to investigate the possible protective effect of Avicennia alba leaves extract on ethanol-induced gastric mucosal damage in Wistar female rats. The experimental animals were divided into five groups. The first group was received saline solution and served as control. The second group was intragastrically received ethanol. The third and fourth groups were pretreated with low dose (100 mg kg-1, BW) and high dose (300 mg kg-1 BW) of A. alba leaves extract and after 1 h they were administrated with ethanol. The fifth and sixth groups were intragastrically received low and high doses of A. alba leaves extract. Ethanol treatment increased the levels of serum creatinine, alanine aminotransferase, aspartate aminotransferase and gamma glutamyl transferase in the second group, while the levels of urea and uric acid were statistically unchanged compared with control group. Histopatholgically, ethanol administration caused severe gastric mucosal damage in rats of the second group. Administration of low dose of A. alba leaves extract significantly decreased the physiological and histopathological alterations induced by ethanol. The pretreatment with high dose of A. alba leaves extract significantly inhibited the ethanol-induced physiological and histopathological changes in rats, confirming its nephroprotective, hepatoprotective and gastroprotective influence. The results suggest that A. alba leaves extract possesses significant nephroprotective, hepatoprotective, gastroprotective and antiulcerogenic properties which could be due to antioxidant action of chemical constituents of A. alba leaves extract.
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