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American Journal of Food Technology
  Year: 2008 | Volume: 3 | Issue: 5 | Page No.: 310-314
DOI: 10.3923/ajft.2008.310.314
 
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Effect of Potassium Bromate on Liver and Blood Constituents of Wistar Albino Rats

Rehab Omer, Afaf I. Abuelgasim and B. Elmahdi

Abstract:
Twenty four Wistar albino rats were divided into 4 groups and treated orally with potassium bromate at doses of 0, 50, 100 and 200 mg kg-1 body weight (b.wt.) for 21 days. Rats received 200 mg kg-1 b.wt. died within 18 days. A significant reduction in Hb, PCV and MCHC values were observed in animals received 200 mg kg-1 b.wt. in the second week while no changes occurred in the groups treated with 50 and 100 mg kg-1 b.wt. The activity of alanine transaminase (ALT) was significantly increased in rats received 100 and 200 mg kg-1 b.wt. of potassium bromate from the first week, while total protein and albumin were significantly decreased from the first week in animals treated with 200 mg kg-1 b.wt. and the second week at the dose 100 mg kg-1 b.wt. Histologically liver degeneration and haemorrhage was evident in the groups treated with 100 and 200 mg kg-1 b.wt. The dose of 50 mg kg-1 b.wt. did not cause any changes compared to the control.
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How to cite this article:

Rehab Omer, Afaf I. Abuelgasim and B. Elmahdi, 2008. Effect of Potassium Bromate on Liver and Blood Constituents of Wistar Albino Rats. American Journal of Food Technology, 3: 310-314.

DOI: 10.3923/ajft.2008.310.314

URL: https://scialert.net/abstract/?doi=ajft.2008.310.314

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