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Asian Journal of Biochemistry
  Year: 2007 | Volume: 2 | Issue: 5 | Page No.: 323-329
DOI: 10.3923/ajb.2007.323.329
 
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TAME-Esterase and Oxidative Stress Contribute to Dysmetabolic Syndrome in Dyslipidaemia

A.H. Subratty , L.H. Semfa and M.D. Manraj

Abstract:
In this study, the level of oxidative stress and TAME-esterase activity in dyslipidaemic patients were studied. Fasting levels of total peroxides, triglycerides, total cholesterol, HDL-cholesterol, fasting and 2 h post load glucose were determined using commercially available kits among 110 individuals (mean age 47.5±8.5 years) subdivided into 3 groups namely: Optimal LDL (LDL<3.4 mmol L-1), Borderline LDL (3.4 = LDL = 4.2 mmol L-1) and High LDL (LDL>4.2 mmol L-1). TAME-esterase activity was assessed using a simple colorimetric micromethod. Data was analysed using Epi-Info statistical software. Analysis of data showed no association between TAME-esterase activity, total peroxides and dyslipidaemia. TAME-esterase activity was higher in patients with abnormal glucose metabolism as compared to normoglycaemic subjects (p<0.05). It was concluded that TAME-esterase and hence the kinin-kallikrein system may play an important role in insulin resistance and endothelial dysfunction.
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How to cite this article:

A.H. Subratty , L.H. Semfa and M.D. Manraj , 2007. TAME-Esterase and Oxidative Stress Contribute to Dysmetabolic Syndrome in Dyslipidaemia. Asian Journal of Biochemistry, 2: 323-329.

DOI: 10.3923/ajb.2007.323.329

URL: https://scialert.net/abstract/?doi=ajb.2007.323.329

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