Submit Manuscript

Pakistan Journal of Biological Sciences

Year: 2013 | Volume: 16 | Issue: 10 | Page No.: 469-476
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 433

Search

Authors

A.C.C. Egbuonu

L.U.S. Ezeanyika

I.I. Ijeh

Keywords

Research Article

Alterations in the Liver Histology and Markers of Metabolic Syndrome Associated with Inflammation and Liver Damage in L-arginine Exposed Female Wistar Albino Rats

A.C.C. Egbuonu, L.U.S. Ezeanyika and I.I. Ijeh
Metabolic Syndrome (MES), a cluster of metabolic disorders, is pandemic and more prevalent in females. It was associated with inflammation, liver damage and reduced nitric oxide concentration. Since L-arginine (ARG) may enhance nitric oxide synthesis, this study investigated the effect of ARG on the liver histology and selected serum markers of MES related to inflammation and liver damage. Two groups (n = 8) of female Wistar albino rats were exposed to 60 mg kg-1 b. wt. of ARG and 3 mL kg-1 b.wt. of distilled water, respectively as treated and control groups. Per oral exposure to ARG for twenty eight days caused a non-significant increase (p>0.05) in the neutrophils count (22.50±10.35%, representing 38.46%) but a decrease (p>0.05) in the lymphocytes count (77.50±10.35%, representing 8.82%) and in the total bilirubin concentration (0.40±0.19 mg/100 mL, representing 52.38%) of the rats, suggesting non-treatment related influence on these parameters. However, the exposure elicited a significant decrease (p<0.01) in the serum alanine aminotransferase (ALT) activity (66.47±0.37 IU L-1, representing 18.55%) and in the total White Blood Cell (WBC) count (2.73±0.75x109 L-1, representing 43.24%), suggesting absence of inflammation and liver damage. ALT had a significant positive correlation with WBC (r = 0.01), while the liver histology revealed possible benefit in the ARG-fed rats, seeminlgly confirming benefit on these markers of inflammation and liver damage that could improve related MES features in the rats. Further studies using ARG rich nuts are required to harness insight gained from this study.
PDF Fulltext XML References Citation

Related Articles

Dysfunctional Liver and other High Metabolic Organs in Asymptomatic Petroleum Depot Workers in Calabar South-South, Nigeria
Comparative Assessment of some Mineral, Amino Acid and Vitamin Compositions of Watermelon (Citrullus lanatus) Rind and Seed
Effect of L-arginine on Some Anthropometric Parameters of Metabolic Syndrome in Normal Female Wistar Rats
Biochemical Effects of Pesticides on Serum and Urinological System of Rats
Preventive Effect of Bridelia ferruginea Against High-fructose Diet Induced Glucose Intolerance, Oxidative Stress and Hyperlipidemia in Male Wistar Rats
Sub-chronic Concomitant Ingestion of L-arginine and Monosodium Glutamate Improves Feed Efficiency, Lipid Metabolism and Antioxidant Capacity in Male Wistar Rats
Dose-related Influence of Esculetin (6,7-dihydroxy-coumarin) on Some Liver and Prostate Function Markers of Male Wistar Rats
Some Biochemical Effects of Sub-Acute Oral Administration of L-Arginine on Monosodium Glutamate-Fed Wistar Albino Rats 2: Serum Alkaline Phosphatase, Total Acid Phosphatase and Aspartate Aminotransferase Activities

Leave a Comment

Your email address will not be published. Required fields are marked *