A. Y. Asmadi
Department of Pharmacology
A. Adam
Faculty of Pharmacy, Universiti Teknologi MARA, Shah Alam, Selangor,
W.Z. Wan Ngah
Department of Biochemistry, Faculty of Medicine,
M. Norazlina
Department of Pharmacology
Y. Kamisah
Department of Pharmacology
M. F. Nur-Azlina
Department of Pharmacology
M. S. Qodriyah
Department of Pharmacology
N. S. Ahmad
Department of Pharmacology
M. T. Gapor
Agro Product Unit, Engineering and Processing Research Division, Malaysian Palm Oil Board, P O Box 10670, 50720 Kuala Lumpur, Malaysia
E-mail: [email protected]
A. Marzuki
Department of Pharmacy, Faculty of Allied Health Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
ABSTRACT
The effect of dietary tocotrienols and α-tocopherol acetate supplementation on paraquat-induced lung toxicity was investigated in rats. The administration of a single dose of paraquat (20 mg/kg, i.p.) to rats increased lung malondialdehyde (MDA) levels and produced lung edema. Tocotrienols (150 mg/kg pellet) or α-tocopherol (34 mg/kg pellet) supplementation of two months significantly reduced lung MDA levels in rats exposed to paraquat but lung edema was unaffected. However lower doses of tocotrienols in the diet did not significantly lower lung MDA levels compared with the unsupplemented controls. Our results showed that dietary supplementation of tocotrienols and α-tocopherol provides protection against paraquat toxicity possibly through their antioxidant property.
How to cite this article
A. Y. Asmadi, A. Adam, W.Z. Wan Ngah, M. Norazlina, Y. Kamisah, M. F. Nur-Azlina, M. S. Qodriyah, N. S. Ahmad, M. T. Gapor and A. Marzuki, 2005. Tocotrienols and α-Tocopherol Reduced Acute and Chronic Lung Lipid Peroxidation Induced by Paraquat in Rats. Pakistan Journal of Nutrition, 4: 97-100.
DOI: 10.3923/pjn.2005.97.100
URL: https://scialert.net/abstract/?doi=pjn.2005.97.100
DOI: 10.3923/pjn.2005.97.100
URL: https://scialert.net/abstract/?doi=pjn.2005.97.100