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Hyperhomocysteinemia, Lifestyle Factors and Cognitive Impairment in Healthy Older Subjects in Jordan



Rima H. Mashal
 
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ABSTRACT

Hyperhomocysteinemia (HHcy) is a well recognized risk factor for cognitive impairment in the elderly. Homocystein levels (Hcy) are influenced by a many factors such as age, gender and some lifestyle factors such as smoking, coffee and tea consumption. The aim of the present study is to explore the relationship among plasma Hcy, lifestyle factors including coffee and tea consumption, smoking and cognitive impairment risk. A cross-sectional sample of 63 healthy Jordanian elderly subjects of either sex of age >60 years were examined. All participants completed a questionnaire about lifestyle and health. Plasma Hcy levels were determined for all subjects. The cognitive function was assessed using Mini-Mental State Exam (MMSE). A significant positive associations were seen between the levels of Hcy and the intake of both tea (B = 1.15, p<0.05) and coffee (B = 2.3, p<0.05). Only age (B = -0.2, p<0.05) and tea intake (B = -0.1, p<0.05) were significantly negatively associated with MMSE scores. Only MMSE scores [0.77 (0.62-0.93); p = 0.00] and tea intake [1.7 (1.1-2.7); p = 0.01] were significantly associated with the risk of HHcy. Smoking and coffee consumption were insignificantly associated with the risk of HHcy. Homocysteine was positively associated with cognitive impairment [1.3 (1.1-1.6); p = 0.00]. Only tea intake was associated with the risk of cognitive impairment [1.8 (1.1-2.8); p = 0.00]. Finally, further studies are needed to elucidate the observed non-significant associations among Hcy levels, smoking, coffee intake and the associated cognitive impairment risk.

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  How to cite this article:

Rima H. Mashal , 2013. Hyperhomocysteinemia, Lifestyle Factors and Cognitive Impairment in Healthy Older Subjects in Jordan. Pakistan Journal of Nutrition, 12: 71-79.

DOI: 10.3923/pjn.2013.71.79

URL: https://scialert.net/abstract/?doi=pjn.2013.71.79

REFERENCES
1:  Balk, E.M., G. Raman, A. Tatsioni, M. Chung, J. Lau and I.H. Rosenberg, 2007. Vitamin B6, B12 and folic acid supplementation and cognitive function: A systematic review of randomized trials. Arch. Internal Med., 167: 21-30.
PubMed  |  

2:  Bates, C.J., M.A. Mansoor, J. van der Pols, A. Prentice, T.J. Cole and S. Finch, 1997. Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over. Eur. J. Clin. Nutr., 51: 691-697.
Direct Link  |  

3:  Budge, M.M., C. de Jager, E. Hogervorst and D. Smith, 2002. Total plasma homocysteine, age, systolic blood pressure and cognitive performance in older people. J. Am. Geriatrics Soc., 50: 2014-2018.
CrossRef  |  

4:  De Bree, A., W.M. Verschuren, D. Kromhout, L.A. Kluijtmans and H.J. Blom, 2002. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol. Rev., 54: 599-618.
PubMed  |  

5:  Diaz-Arrastia, R., 2000. Homocysteine and neurologic disease. Arch. Neurol., 57: 1422-1427.
CrossRef  |  

6:  Elias, M.F., M.A. Robbins, M.M. Budge, P.K. Elias and S.L. Brennan et al., 2006. Homocysteine, folate and vitamins B6 and B12 blood levels in relation to cognitive performance: The maine-syracuse study. Psychosomatic Med., 68: 547-554.
Direct Link  |  

7:  El-Khairy, L., P.M. Ueland, O. Nygard, H. Refsum and S.E. Vollset, 1999. Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: The hordaland homocysteine study. Am. J. Clin. Nutr., 70: 1016-1024.
Direct Link  |  

8:  Folstein, M.F., S.E. Folstein and P.R. Mc Hugh, 1975. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res., 12: 189-198.
CrossRef  |  PubMed  |  Direct Link  |  

9:  Garcia, A. and K. Zanibbi, 2004. Homocysteine and cognitive function in elderly people. Can. Med. Assoc. J., 171: 897-903.

10:  Ganji, V. and M.R. Kafai, 2005. Trends in serum folate, RBC folate and circulating total homocysteine concentrations in the United States: Analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000 and 2001-2002. J. Nutr., 136: 153-158.
PubMed  |  Direct Link  |  

11:  Harland, B.F., 2000. Caffeine and nutrition. Nutrition, 16: 522-526.
PubMed  |  Direct Link  |  

12:  Huijbregts, P.P., E.J. Feskens, L. Rasanen, F. Fidanza and A. Alberti-Fidanza et al., 1998. Dietary patterns and cognitive function in elderly men in Finland, Italy and the Netherlands. Eur. J. Clin. Nutr., 52: 826-831.
PubMed  |  Direct Link  |  

13:  Jacques, P.F., A.G. Bostom, P.W.F. Wilson, S. Rich, I.H. Rosenberg and J. Selhub, 2001. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am. J. Clin. Nutr., 73: 613-621.
Direct Link  |  

14:  Feng, L., T.P. Ng, L. Chuah, M. Niti and E.H. Kua, 2006. Homocysteine, folate and vitamin B-12 and cognitive performance in older Chinese adults: Findings from the Singapore longitudinal ageing study. Am. J. Clin. Nutr., 84: 1506-1512.
Direct Link  |  

15:  Lokk, J., 2003. News and views on folate and elderly persons. J. Gerontol. A Biol. Sci. Med. Sci., 58: 354-361.
PubMed  |  Direct Link  |  

16:  Mashal, R.H. and A. Odeh, 2004. Plasma homocysteine levels and coronary heart disease risk in Jordanian subjects. JRMS, 11: 7-16.

17:  McKay, D.L. and J.B. Blumberg, 2002. The role of tea in human health: An update. J. Am. Coll. Nutr., 21: 1-13.
PubMed  |  

18:  MOH, 1991. Ten-year plan (1997-2006) for control of cardiovascular diseases in Jordan. Ministry of Health (MOH), Amman, Jordan.

19:  Moghadisian, M.H., B.M. McManus and J.J. Frohlich, 1997. Homocyst (e) ine and coronary artery disease. Arch. Int. Med., 157: 2299-2308.

20:  Moustapha, A. and K. Robinson, 1999. Homocysteine: An emerging age-related cardiovascular risk factor. Geriatrics, 54: 41-44.
PubMed  |  

21:  Morris, M.S., P.F. Jacques, J. Selhub and I.H. Rosenberg, 2000. Total homocysteine and estrogen status indicators in the third national health and nutrition examination survey. Am. J. Epidemiol., 152: 140-148.

22:  Nygard, O., J.E. Nordrehaug, H. Refsum, P.M. Ueland, M. Farstad and S.E. Vollset, 1997. Plasma homocysteine levels and mortality in patients with coronary artery disease. N. Engl. J. Med., 337: 230-237.
CrossRef  |  PubMed  |  Direct Link  |  

23:  Olthof, M.R., P.C. Hollman, P.L. Zock and M.B. Katan, 2001. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am. J. Clin. Nutr., 75: 532-538.
PubMed  |  Direct Link  |  

24:  Rasmussen, L.B., L. Ovesen, I. Bulow, N. Knudsen, P. Laurberg and H. Perrild, 2000. Folate intake, lifestyle factors and homocysteine concentrations in younger and older women. Am. J. Clin. Nutr., 72: 1156-1163.
Direct Link  |  

25:  Refsum, H., A.D. Smith, P.M. Ueland, E. Nexo and R. Clarke et al., 2004. Facts and recommendations about total homocysteine determinations: An expert opinion. Clin. Chem., 50: 3-32.
CrossRef  |  

26:  Refsum, H., E. Nurk, A.D. Smith, P.M. Ueland and C.G. Gjesdal et al., 2006. The hordaland homocysteine study: A community-based study of homocysteine, its determinants and associations with disease. J. Nutr., 136: 1731S-1740S.
Direct Link  |  

27:  Rydlewicz, J.A. Simpson, R.J. Taylor, C.M. Bond and M.H.N. Golden, 2002. The effect of folic acid supplementation on plasma homocysteine in an elderly population. QJM, 95: 27-35.
CrossRef  |  

28:  Saw, S.M., J.M. Yuan, C.N. Ong, K. Arakawa, H.P. Lee, G.A. Coetzee and M.C. Yu, 2001. Genetic, dietary and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am. J. Clin. Nutr., 73: 232-239.
Direct Link  |  

29:  Schneede, J., H. Refsum and P.M. Ueland, 2000. Biological and environmental determinants of plasma homocysteine. Semin. Thromb. Homeost., 26: 263-279.
PubMed  |  Direct Link  |  

30:  Smith, A.D. and H. Refsum, 2009. Vitamin B 12 and cognition in the elderly. Am. J. Clin. Nutr., 89: 707S-711S.
CrossRef  |  

31:  Stolzenberg-Solomon, R.Z., E.R. Miller, M.G. Maguire, J. Selhub and L.J. Appel, 1999. Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population. Am. J. Clin. Nutr., 69: 467-475.
Direct Link  |  

32:  SPSS, 1998. SPSS Base 10.0 for Windows. SPSS, Chicago, Illinois, USA.

33:  Tani, J., I. Tedja, I.R. Widjaja, S. Bardosono and Z. Amri, 2008. Dietary vitamins B, folic acid and cognitive impairment in the elderly. J. Indonesian Med. Assoc., Vol. 58. http://indonesia.digitaljournals.org/index.php/idnmed/article/view/571

34:  Tassino, M., T.F. Campos and R.O. Guerra, 2009. Homocysteine (Hcy) and cognitive performance in a population sample of elderly Brazilians. Arch. Gerontol. Geriatrics, 48: 142-145.
CrossRef  |  

35:  Tomata, Y., M. Kakizaki, N. Nakaya, T. Tsuboya, T. Sone, S. Kuriyama, A. Hozawa and I. Tsuji, 2012. Green tea consumption and the risk of incident functional disability in elderly Japanese: The ohsaki cohort 2006 study. Am. J. Clin. Nutr., 95: 732-739.
CrossRef  |  

36:  Tucker, K.L. and S. Buranapin, 2001. Nutrition and aging in developing countries. J. Nutr., 131: 2417S-2423S.
Direct Link  |  

37:  Tucker, K.L., N. Qiao, T. Scott, I. Rosenberg and A. Spiro III, 2005. High homocysteine and low B vitamins predict cognitive decline in aging men: The Veterans affairs normative aging study. Am. J. Clin. Nutr., 82: 627-635.
PubMed  |  Direct Link  |  

38:  Ng, T.P., L. Feng, M. Niti, E.H. Kua and K.B. Yap, 2008. Tea consumption and cognitive impairment and decline in older Chinese adults. Am. J. Clin. Nutr., 88: 224-231.
PubMed  |  Direct Link  |  

39:  Urgert, R., T. van Vliet, P.L. Zock and M.B. Katan, 2000. Heavy coffee consumption and plasma homocysteine: A randomized controlled trial in healthy volunteers. Am. J. Clin. Nutr., 72: 1107-1110.
PubMed  |  Direct Link  |  

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