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Journal of Biological Sciences

Year: 2009 | Volume: 9 | Issue: 3 | Page No.: 288-291
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Authors

S.K. Sharma

J. Mahanta

Keywords

Short Communication

Prevalence of Haemoglobin Variants in Malaria Endemic Northeast India

S.K. Sharma and J. Mahanta
The present study is an attempt to evaluate the relationship of haemoglobinopathies, particularly Hb E and Plasmodium falciparum malaria in northeastern region of India. The diverse autochthonous inhabitant of this part of India exhibits variable gene frequency for βE-globin gene. The geo-climatic condition of the region supports transmission of Plasmodium falciparum malaria in northeastern parts of India. The study revealed that HbE is predominant with a variable gene frequencies in ethnic groups affiliated to Tibeto-Burman linguistic families. Prevalence of Hb E is also associated with the linguistic affiliation of various Tibeto-Burman linguistic families inhabiting in malaria endemic northeast India. We have also observed a positive correlation (R2 = 0.703) of βE-globin gene frequency and mean incidence of Plasmodium falciparum infection (Pf %) in malaria endemic zones.
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