Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 5 | Page No.: 393-397
DOI: 10.3923/ijp.2008.393.397
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Potentiating Effect of Piperine on Hepatoprotective Activity of Boerhaavia diffusa to Combat Oxidative Stress

S.K. Desai, V.S. Gawali, A.B. Naik and L.L. D`souza

Abstract:
The hydro alcoholic extract of roots of Boerhaavia diffusa (HEBD) was evaluated for its hepatoprotective activity against CCl4 and Rifampicin - Isoniazid combination induced hepatotoxicity at two dose levels 150 and 300 mg kg-1 . HEBD exhibited a significant protective action on the liver evident by a reduction in the elevated levels of serum lysosomal enzymes namely Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transminase (SGOT), Alkaline Phosphatase (ALP) in both CCl4 and Rifampicin-Isoniazid induced hepatotoxicity. Thus HEBD showed a dose dependent hepatoprotective activity. In addition, the hepatoprotective activity of Boerhaavia diffusa was evaluated for possible potentiation in the presence of piperine based on recent research which has reported the latter enhancing bioavailability of certain drugs and nutritional compounds. Piperine was checked for potentiation, if any, at two dose levels 10 and 20 mg, respectively. Piperine was found to produce a dose dependent potentiation of the hepatoprotective activity of Boerhaavia diffusa.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Boerhaavia diffusa Linn.: A Review on its Phytochemical and Pharmacological Profile
How to cite this article:

S.K. Desai, V.S. Gawali, A.B. Naik and L.L. D`souza, 2008. Potentiating Effect of Piperine on Hepatoprotective Activity of Boerhaavia diffusa to Combat Oxidative Stress. International Journal of Pharmacology, 4: 393-397.

DOI: 10.3923/ijp.2008.393.397

URL: https://scialert.net/abstract/?doi=ijp.2008.393.397

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 



Curve Bottom