Submit Manuscript

International Journal of Pharmacology

Year: 2008 | Volume: 4 | Issue: 5 | Page No.: 393-397
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 74

Authors

S.K. Desai

V.S. Gawali

A.B. Naik

L.L. D`souza

Keywords

Research Article

Potentiating Effect of Piperine on Hepatoprotective Activity of Boerhaavia diffusa to Combat Oxidative Stress

S.K. Desai, V.S. Gawali, A.B. Naik and L.L. D`souza
The hydro alcoholic extract of roots of Boerhaavia diffusa (HEBD) was evaluated for its hepatoprotective activity against CCl4 and Rifampicin - Isoniazid combination induced hepatotoxicity at two dose levels 150 and 300 mg kg-1 . HEBD exhibited a significant protective action on the liver evident by a reduction in the elevated levels of serum lysosomal enzymes namely Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transminase (SGOT), Alkaline Phosphatase (ALP) in both CCl4 and Rifampicin-Isoniazid induced hepatotoxicity. Thus HEBD showed a dose dependent hepatoprotective activity. In addition, the hepatoprotective activity of Boerhaavia diffusa was evaluated for possible potentiation in the presence of piperine based on recent research which has reported the latter enhancing bioavailability of certain drugs and nutritional compounds. Piperine was checked for potentiation, if any, at two dose levels 10 and 20 mg, respectively. Piperine was found to produce a dose dependent potentiation of the hepatoprotective activity of Boerhaavia diffusa.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *