• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 2 (2), 2006
  3. 226-232
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 2 | Page No.: 226-232
DOI: 10.3923/ijp.2006.226.232

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 394

Search


Authors


Abdulhakeem A. Al-Majed


Keywords


  • somatic and sex cells
  • Guarana
  • cytology
  • nucleic acids
  • NP-SH
  • MDA
Research Article

Genetic and Biochemical Toxicity of Guarana After Sub-Acute Treatment in Somatic and Germ Cells of Swiss Albino Mice

Abdulhakeem A. Al-Majed
Paulinia cupana (Guarana) was evaluated for cytological and biochemical toxicity in male mice. Mice were orally treated with 133, 265 and 530 mg/kg/day of the aqueous suspension of Guarana for 7 consecutive days. The following parameters were evaluated: (I) studies on micronucleus test, (ii) analysis of spermatozoa abnormalities, (iii) analysis of meiotic chromosomes, (iv) quantification of proteins, Ribose Nucleic Acid (RNA) and Deoxy Ribose Nucleic Acid (DNA) in hepatic and testicular cells and (v) estimation of malondialdehyde (MDA) and nonprotein sulfhydryl (NP-SH) in hepatic and testicular cells. The treatment caused significant changes in the frequency of micronuclei in the femoral cells and induced testicular chromosomal aberrations. However, there was no effect on the morphology of spermatozoa. The study on biochemical parameters showed increase of MDA and depletion of NP-SH, RNA and DNA in both hepatic and testicular cells. Present data elucidated the role of free radical species in cytological and biochemical changes in both somatic and germ cells. The exact mechanism of the genesis of lipid peroxides is not known, however, this might be related to the influence of the tannin contents of Guarana. It is suggested that, in view of the observed cytological and biochemical effects of Guarana, it may be subjected to a thorough evaluation of toxicity before it is available for human use.
PDF Fulltext XML References Citation

How to cite this article

Abdulhakeem A. Al-Majed, 2006. Genetic and Biochemical Toxicity of Guarana After Sub-Acute Treatment in Somatic and Germ Cells of Swiss Albino Mice. International Journal of Pharmacology, 2: 226-232.

DOI: 10.3923/ijp.2006.226.232

URL: https://scialert.net/abstract/?doi=ijp.2006.226.232

Related Articles

Observations on Chromosomal Aberrations Following the Administration of Methanol Sub-Fraction of Carica papaya Seeds for Contraception in Albino Rats and Rabbits

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved