
	International Journal of Pharmacology
	Year: 2011 \| Volume: 7 \| Issue: 6 \| Page No.: 721-725 DOI: 10.3923/ijp.2011.721.725

Observations on Chromosomal Aberrations Following the Administration of Methanol Sub-Fraction of Carica papaya Seeds for Contraception in Albino Rats and Rabbits

A.S. Ansari, S. Shrivastava, S. Goyal and N.K. Lohiya

Abstract: The seed products of Carica papaya have been proven as potential male contraceptives in laboratory animals. In this study, chromosomal aberrations were investigated in spermatogonia of albino rats and rabbits, following oral administration of Methanol Sub-Fraction (MSF) of Carica papaya seeds. The experimental animals were divided into three groups, each group had 5 male Wistar rats and rabbits. In the first group, double distilled water served as negative control. The second group received monomeric acrylamide at 72.5 mg kg^-1 body weight; two doses with a gap of 3 h served as positive control and in the third group, the MSF was orally administered at 500 mg kg^-1 body weight (10 x contraceptive dose; CD); two doses with a gap of 3 h. The chromosomal fragments, dicentrics, rings, exchanges, damaged chromosomes and total chromosomal aberrations in MSF treated rats and rabbits were not significantly different when compared with negative control animals, however, were found to be reduced significantly (p<0.001) when compared with positive control group. The results suggested that the MSF did not induce chromosomal aberrations.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Plants for Female Fertility Regulation: A Review

•	Genetic and Biochemical Toxicity of Guarana After Sub-Acute Treatment in Somatic and Germ Cells of Swiss Albino Mice

•	Safety Evaluation of Long Term Treatment of Methanol Sub-Fraction of Seeds of Carica papaya as a Male Contraceptive with Particular Emphasis on Carcinogenicity in Albino Rats

How to cite this article:

A.S. Ansari, S. Shrivastava, S. Goyal and N.K. Lohiya, 2011. Observations on Chromosomal Aberrations Following the Administration of Methanol Sub-Fraction of Carica papaya Seeds for Contraception in Albino Rats and Rabbits. International Journal of Pharmacology, 7: 721-725.

DOI: 10.3923/ijp.2011.721.725

URL: https://scialert.net/abstract/?doi=ijp.2011.721.725

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		Thomson ISI

Science Alert