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Neuroendocrinological, Metabolic and Toxicological Effects of Chronic Cannabis Use among Male in Lagos |
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T.A. Samuel,
H.S.A. Olasore,
E.O. Nanaghan,
I.O. Turner,
A.A. Owoyale and O.A. Magbagbeola |
Abstract:
Controversies surround the use of cannabis and there have been discrepancies
in the results of various studies on cannabis carried out on animals and on
human beings. The aim of this study was to investigate the toxicological, metabolic,
reproductive and neurochemical effects of chronic cannabis use among some male
users in Lagos, Nigeria. Twenty male chronic cannabis smokers with ages between
20-35 years and average duration of cannabis use of 5 years were recruited along
with ten male age matched controls that were not using cannabis. Blood samples
were collected from all the subjects for the analyses of plasma dopamine, norepinephrine,
Prolactin (PRL), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH)
and testosterone levels. Random blood sugar, plasma cholesterol, High Density
Lipoprotein (HDL)-cholesterol, Low Density Lipoprotein (LDL)-cholesterol, triglycerides,
total plasma protein, serum Alanine Transaminase (ALT) and Aspartate Aminotransferase
(AST) were also estimated. The results showed that smokers had significantly
higher levels of dopamine, norepinephrine and testosterone. There was also significantly
higher levels of serum ALT and AST in the smokers’
group. However, the other reproductive hormones and the metabolic parameters
checked were all not significantly different between the two groups. We concluded
that chronic cannabis use is associated with increased catecholamine neurotransmitters
and increased testosterone and liver toxicity while there are no effects on
PRL and gonadotropins as well as metabolism.
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How to cite this article:
T.A. Samuel, H.S.A. Olasore, E.O. Nanaghan, I.O. Turner, A.A. Owoyale and O.A. Magbagbeola, 2012. Neuroendocrinological, Metabolic and Toxicological Effects of Chronic Cannabis Use among Male in Lagos. Asian Journal of Biochemistry, 7: 226-231.
DOI: 10.3923/ajb.2012.226.231
URL: https://scialert.net/abstract/?doi=ajb.2012.226.231
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