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Journal of Biological Sciences

Year: 2009 | Volume: 9 | Issue: 8 | Page No.: 884-888
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Authors

M. Tehranipour

S. Ebrahimpour

Keywords

Research Article

Evaluating the Effect of Aquatic Extract of Cannabis sativa Seed on Spatial Memory Consolidation in Rats

M. Tehranipour and S. Ebrahimpour
As the point of physiology, memory form, from changes in the conducting message in the neural webs. These changes cause to formation of long-term potentiation. Δ9-THC is Psychotropic component 4-of Cannabis sativa plant; studies show this matter can bind cannabinoid receptor in CA1 area of hippocampus. Thus the aim of this study is evaluation the effect of aquatic extraction Cannabis sativa seed on spatial 7-memory consolidation in Rats. Forty male wistar Rats (3-4 mounth, 320-260 g) were completely divided into 4 experimental groups and control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days, 4 trails) was used. Experimental groups with 50, 100, 150 and 210 mg kg-1 were injected in the peritoneal (IP) and after 1 h of injection spatial memory was scaled. The result show that experimental groups (50, 100 and 150 mg kg-1 doses), for learning time have significant level deduction in the comparison of control group (p<0.05), but experimental group with 18-210 mg kg-1 dose has not significant level in the comparison of control group (p<0.05). This LTP probably was done with Depolarization Induced Suppression of excitatory (DSE) mechanism in the CA1 area of Hippocampus that with neurotransmitter regulation cause to neuroplasticity.
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