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Research Journal of Medicinal Plants
  Year: 2012 | Volume: 6 | Issue: 1 | Page No.: 74-82
DOI: 10.3923/rjmp.2012.74.82
 
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Chemical Constituents and Cytotoxic Activity of Polyalthia cauliflora var. cauliflora

N.A. Ghani, N. Ahmat, N.H. Ismail, I. Zakaria and N.K.N.A. Zawawi

Abstract:
Phytochemical investigation of the stem bark of Polyalthia cauliflora var. cauliflora has led to the isolation of two chalcones and an alkaloid; 2’, 4’-dihydroxy-3’-methoxychalcone (1), 2’, 4’-dihydroxychalcone (2) and liriodenine (3). 2’, 4’-dihydroxy-3’-methoxychalcone (1) n was found to be cytotoxic against HL-60, MCF-7 and HeLa cancer cell lines with IC50 value of 12.2, 5.1 and 12.5 μg mL-1, respectively. 2’, 4’-dihydroxy-3’-methoxychalcone may prove to be useful in cancer treatment and prevention. The aims of this study were to extract, fractionate and isolate the chemical constituents from the stem bark of Polyalthia cauliflora var. cauliflora. Various chromatographic techniques including glass column chromatography, preparative thin layer chromatography and centrifugal chromatography had been used in this study. The isolated compounds were elucidated using several spectroscopic techniques including 1H and 13C NMR, IR, UV-Vis, mass spectroscopy and comparison with literature. Potential and sufficient amount of compounds were subjected to cytotoxic activity against HL-60, MCF-7 and HeLa cancer cell lines.
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How to cite this article:

N.A. Ghani, N. Ahmat, N.H. Ismail, I. Zakaria and N.K.N.A. Zawawi, 2012. Chemical Constituents and Cytotoxic Activity of Polyalthia cauliflora var. cauliflora. Research Journal of Medicinal Plants, 6: 74-82.

DOI: 10.3923/rjmp.2012.74.82

URL: https://scialert.net/abstract/?doi=rjmp.2012.74.82

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