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Effect of Costus afer Leaves’
Juice on Nitrocellulose Thinner Induced Nephrotoxicity in Rats |
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F.E. Uboh,
Saviour Ufot,
Eve Mboso and E.U. Eyong |
Abstract:
This study assessed the effect of oral administration of Costus afer
leaves’ juice (CALJ) on the functional
integrity of the renal tissues in rats orally exposed to nitrocellulose thinner
(NCT). Three groups of six rats each, were orally administered distilled water,
NCT (30.0 mg kg-1 b.wt.) and NCT (30.0 mg kg-1 b.wt.)
in combination with 600 mg kg-1 b.wt. of CALJ (one hour before NCT
administration), respectively for 28 days. The animals were sacrificed after
12 h fast, on the 29th day of the experiment, blood collected through cardiac
puncture for serum urea, Blood Urea Nitrogen (BUN), uric acid, creatinine, kidneys
for renal tissues malondialdehyde (MDA), Glutathione Peroxidase (GPx) and Superoxide
Dismutase (SOD) activities determination. The results showed that NCT caused
a significant (p<0.05) increase in serum urea, BUN, uric acid, creatinine
and renal tissue MDA levels, as well as decrease in renal tissue GPx and SOD
activities, compared to control group. These results indicated that NCT’s
constituents and their metabolites are nephrotoxic. However, it was observed
that administration of CALJ protected the renal tissues against the NCT-induced
nephrotoxicity, as indicated by the restoration of serum urea, BUN, uric acid
and creatinine levels, as well as renal tissue MDA, GPx and SOD activities to
the control range. Also the tubular epithelial necrosis and atrophy of the glomeruli,
observed to be associated with exposure to NCT were restored to normal on treatment
with CALJ. This study strongly suggested that CALJ’s
constituents possess a protective effect against NCT-induced renal tissues damage
and reflected the beneficial role of Costus afer in the treatment of
various clinical disorders.
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How to cite this article:
F.E. Uboh, Saviour Ufot, Eve Mboso and E.U. Eyong, 2014. Effect of Costus afer Leaves’
Juice on Nitrocellulose Thinner Induced Nephrotoxicity in Rats. Research Journal of Environmental Toxicology, 8: 37-45.
DOI: 10.3923/rjet.2014.37.45
URL: https://scialert.net/abstract/?doi=rjet.2014.37.45
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