
	Pakistan Journal of Biological Sciences
	Year: 2005 \| Volume: 8 \| Issue: 10 \| Page No.: 1397-1401 DOI: 10.3923/pjbs.2005.1397.1401

Hepatoprotective Activity of Hibiscus cannabinus (Linn.) Against Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats

Gabriel A. Agbor , Julius E. Oben , Blaise Nkegoum , Jean Pierre Takala and Jeanne Y. Ngogang

Abstract: In the present study the hepatoprotective activity of a daily oral dose (1.6 g kg^-1) of aqueous leaf extract of H. cannabinus was investigated over a two week period in albino rats. Liver damage in rats was induced using Carbon tetrachloride (CCl₄) and Paracetamol (PCM). This was confirmed by increased plasma transaminases activities, total bilirubin concentration and Thiobarbituric Acid Reactive substance (TBRs, a measure of lipid peroxidation). Histopathological examinations substantiated this liver damage with fatty deposits, severe inflammation and severe necrosis. The aqueous leaf extract of H. cannabinus showed a significant (p<0.05) hepatoprotective activity against this damage in lowering the plasma transaminases and bilirubin concentration significantly (p<0.05). Absents of necrosis in liver cells of rats pretreated with extract indicated a protective effect. The extract also inhibited lipid peroxidation, suggesting a possible mechanism of action. The results obtained confirm the hepatoprotective activity of H. cannabinus.

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How to cite this article:

Gabriel A. Agbor , Julius E. Oben , Blaise Nkegoum , Jean Pierre Takala and Jeanne Y. Ngogang , 2005. Hepatoprotective Activity of Hibiscus cannabinus (Linn.) Against Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats. Pakistan Journal of Biological Sciences, 8: 1397-1401.

DOI: 10.3923/pjbs.2005.1397.1401

URL: https://scialert.net/abstract/?doi=pjbs.2005.1397.1401

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