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Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 3 | Page No.: 158-165
DOI: 10.3923/jpt.2012.158.165
 
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Acute and Subacute Toxicity Studies of Aqueous Extract of Morinda lucida Stem Bark

G.A. Agbor, P.A. Tarkang, J.V.Z. Fogha, L.F. Biyiti, V. Tamze, H.M. Messi, N. Tsabang, F. Longo, A.T. Tchinda, B. Dongmo, N.T. Donfagsiteli, J.N. Mbing, K. Joseph, R.A. Ngide and D. Simo

Abstract:
Morinda lucida is used as a remedy for diabetes and some other diseases in African folk medicine. In an acute toxicity study, Morinda lucida extract was administered orally at doses ranging between 2-20 g kg-1 to experimental mice and observed for any toxic symptoms up to 14 days. In the sub-acute toxicity, Morinda lucida stem bark extract was tested at dose levels of 0.1, 1 and 5 mg kg-1 on physical (body weight and organ weight), biochemical parameter and histopathological examination in adult male Albino rats. The Morinda lucida extract was well tolerated at the acute administration. No mortality was observed even at the highest dose of 20 g kg-1. In the sub-acute administration, Morinda lucida extract significantly (p<0.05) prevented an increase in body weight in a dose dependent manner and this reflected a significant (p<0.05) increase in the relative organs (liver, heart, kidney and spleen) weights. The biochemical parameters showed a significant (p<0.05) increase in ALT and AST at the dose level of 5 g kg-1 in both two weeks and four weeks examination. Extract had a significant (5<0.05) dose reducing effect on creatinine and triglycerides at 2 weeks administration while at four weeks extract had significant reduction effect on glucose creatinine, cholesterol and triglyceride at dose level of 5 g kg-1. The histopathological examination revealed steatosis in the liver at 5 g kg-1 Morinda lucida extract administration. Thus M. lucida aqueous extract is well tolerated at low dose administration but may be toxic at dose level of 5 g kg-1 at sub-acute administration.
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How to cite this article:

G.A. Agbor, P.A. Tarkang, J.V.Z. Fogha, L.F. Biyiti, V. Tamze, H.M. Messi, N. Tsabang, F. Longo, A.T. Tchinda, B. Dongmo, N.T. Donfagsiteli, J.N. Mbing, K. Joseph, R.A. Ngide and D. Simo, 2012. Acute and Subacute Toxicity Studies of Aqueous Extract of Morinda lucida Stem Bark. Journal of Pharmacology and Toxicology, 7: 158-165.

DOI: 10.3923/jpt.2012.158.165

URL: https://scialert.net/abstract/?doi=jpt.2012.158.165

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