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Pharmacologia

Year: 2013 | Volume: 4 | Issue: 7 | Page No.: 469-480
Review Article

Perspective on Plant Products as Antimicrobials Agents: A Review

A.K. Pandey
Department of Biochemistry, University of Allahabad, Allahabad, 211002, India
Shashank Kumar
Department of Biochemistry, University of Allahabad, Allahabad, 211002, India
Background: The use of plants for healing purposes predates recorded history and forms the origin of much of modern medicine. Many conventional drugs originated from plant sources. Since new and re-emerging infectious diseases are rising very rapidly, there is an urgent need to discover newer antimicrobial compounds having diverse chemical structures and novel mechanisms of action. The emergence of multiple drug resistant strains in human pathogenic organisms has further necessitated the search for new antimicrobial substances from natural sources including plants. This review deals with the phytomedicine usage, the emergence of resistance in the microorganisms, the chemistry and biological activity of the plant based antimicrobial compounds. Results: Medicinal plants have drawn the attention of the researchers worldwide and numerous publications have documented the therapeutic potential of phytochemicals to validate claims of their biological activity. Plants have limitless ability to synthesize aromatic substances, most of which are secondary metabolites including phenols, flavonoids, coumarins, alkaloids and terpenoids etc. These compounds serve as plant defense mechanisms against predation by herbivores, insects and microorganisms. Many plant products have ability to overcome resistance in organisms and thereby combat infectious diseases. This has led researchers to isolate active compounds, investigate their mechanisms of action and provide molecular mechanism of overcoming resistance in microorganisms. Antimicrobial agents are compounds capable of destroying or inhibiting micro-organisms even at low concentrations. They vary in their spectrum of activity and can be classified as antibacterial, antifungal or antiviral agents. Conclusion: Phytomedicines have shown great promise in the treatment of infectious diseases including opportunistic infections. The diversity of phytochemicals present in plants including secondary metabolites provide drug leads for the development of novel therapeutic antibacterial, antifungal and antiviral agents. The review also sheds light on the future development of combination therapy involving plant-derived agents which is indeed very promising.
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References

  1. Adesina, S.K., O. Idowu, A.O. Ogundaini, H. Oladimeji, T.A. Olugbade, G.O. Onawunmi and M. Pais, 2000. Antimicrobial constituents of the leaves of Acalypha wilkesiana and Acalypha hispida. Phytother. Res., 14: 371-374.
    Direct Link
  2. Alanis, A.J., 2005. Resistance to antibiotics: Are we in the post-antibiotic era? Arch. Med. Res., 36: 697-705.
    CrossRefPubMedDirect Link
  3. Alviano, D.S. and C.S. Alviano, 2009. Plant extracts: Search for new alternatives to treat microbial diseases. Curr. Pharm. Biotechnol., 10: 106-121.
    Direct Link
  4. Bandow, J.E., H. Brotz, L.I.O. Leichert, H. Labischinski and M. Hecker, 2003. Proteomic approach to understanding antibiotic action. Antimicro. Agents Chem., 47: 948-955.
    CrossRefPubMedDirect Link
  5. Baris, O., M. Gulluce, F. Sahin, H. Ozer and H. Kilic et al., 2006. Biological activities of the essential oil and methanol extract of Achillea biebersteinii Afan. (Asteraceae). Turk. J. Biol., 30: 65-73.
    Direct Link
  6. Barker, J.J., 2006. Antibacterial drug discovery and structure-based design. Drug Discovery Today, 11: 391-404.
    CrossRefDirect Link
  7. Bartroli, J., E. Turmo, M. Alguero, E. Boncompte and M.L. Vericat et al., 1998. New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones. J. Med. Chem., 41: 1869-1882.
    CrossRefPubMedDirect Link
  8. Chakrabarty, A.M., 2003. Microorganisms and cancer: Quest for therapy. J. Bacteriol., 185: 2683-2686.
    Direct Link
  9. Ciocan, I.D. and I.I. Bara, 2007. Plant products as antimicrobial agents. Genet. Biol. Mol., 8: 151-156.
  10. Cowan, M.M., 1999. Plant products as antimicrobial agents. Clin. Microbiol. Rev., 12: 564-582.
    CrossRefPubMedDirect Link
  11. Cragg, G.M., D.J. Newman and K.M. Snader, 1997. Natural products in drug discovery and development. J. Nat. Prod., 60: 52-60.
    CrossRefPubMedDirect Link
  12. Critchfield, J.W., S.T. Butera and T.M. Folks, 1996. Inhibition of HIV activation in latently infected cells by flavonoid compounds. AIDS Res. Hum. Retroviruses, 12: 39-46.
    Direct Link
  13. Clercq, D.E., 1995. Antiviral therapy for human immunodeficiency virus infections. Microbiol. Rev., 8: 200-239.
    Direct Link
  14. Dean, D.A. and K.W. Burchard, 1996. Fungal infection in surgical patients. Am. J. Surg., 171: 374-382.
    CrossRefDirect Link
  15. Di Domenico, B., 1999. Novel antifungal drugs. Curr. Opin. Microbiol., 2: 509-515.
    CrossRefDirect Link
  16. Doughari, J.H., I.S. Human, S. Bennade and P.A. Ndakidemi, 2009. Phytochemicals as chemotherapeutic agents and antioxidants: Possible solution to the control of antibiotic resistant verocytotoxin producing bacteria. J. Med. Plants. Res., 3: 839-848.
    Direct Link
  17. Eloff, J.N., 1998. Which extractant should be used for the screening and isolation of antimicrobial components from plants? J. Ethnopharmacol., 60: 1-8.
    CrossRefDirect Link
  18. EUCAST., 2003. Determination of Minimum Inhibitory Concentrations (MICs) of antibacterial agents by broth dilution. Clin. Microbiol. Infect., 9: 1-7.
    Direct Link
  19. Fabio, A., C. Cermelli, G. Fabio, P. Nicoletti and P. Quaglio, 2007. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. Phytother. Res., 21: 374-377.
    Direct Link
  20. Ferrazzano, G.F., I. Amato, A. Ingenito, A. Zarrelli, G. Pinto and A. Pollio, 2011. Plant polyphenols and their anti-cariogenic properties: A review. Molecules, 16: 1486-1507.
    CrossRefDirect Link
  21. Ficker, C.E., J.T. Arnason, P.S. Vindas, L.P. Alvarez and K. Akpagana et al., 2003. Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses, 46: 29-37.
    CrossRefDirect Link
  22. Furiga, A., A. Lonvaud-Funel and C. Badet, 2009. In vitro study of antioxidant capacity and antibacterial activity on oral anaerobes of a grape seed extract. Food. Chem., 113: 1037-1040.
    CrossRefDirect Link
  23. Ghosh, A., B.K. Das, A. Roy, B. Mandal and G. Chandra, 2008. Antibacterial activity of some medicinal plant extracts. J. Nat. Med., 62: 259-262.
    CrossRefDirect Link
  24. Gibbons, S., 2003. An overview of plant extracts as potential therapeutics. Exp. Opin. Ther. Pat., 13: 489-497.
    CrossRefDirect Link
  25. Godowski, K.C., 1989. Antimicrobial action of sanguinarine. J. Clin. Dent., 1: 96-101.
    PubMed
  26. Gonzalez, C.E., D. Venzon, S. Lee, B.U. Mueller, P.A. Pizzo and T.J. Walsh, 1996. Risk factors for fungemia in children infected with human immunodeficiency virus: A case-control study. Clin. Infect. Dis., 23: 515-521.
    PubMed
  27. Gonzalez-Lamothe, R., G. Mitchell, M. Gattuso, M.S. Diarra, F. Malouin and K. Bouarab, 2009. Plant antimicrobial agents and their effects on plant and human pathogens. Int. J. Mol. Sci., 10: 3400-3419.
    CrossRefDirect Link
  28. Grayer, R.J. and J.B. Harborne, 1994. A survey of antifungal compounds from higher plants, 1982-1993. J. Phytochem., 37: 19-42.
    CrossRefDirect Link
  29. Gregoire, S., A.P. Singh, N. Vorsa and H. Koo, 2007. Influence of cranberry phenolics on glucan synthesis by glucosyltransferases and Streptococcus mutans acidogenicity. J. Applied Microbiol., 103: 1960-1968.
    CrossRefDirect Link
  30. Groll, A.H., S.C. Piscitelli and T.J. Walsh, 1998. Clinical pharmacology of systemic antifungal agents: A comprehensive review of agents in clinical use, current investigational compounds and putative targets for antifungal drug development. Adv. Pharmacol., 44: 343-500.
    CrossRef
  31. Grollier, J.F., L. Garnier and B. Boussouira, 2009. Cosmetic treatment process based on fruit or vegetable polyphenols. International Publication No. WO2009109946 A1, September 11, 2009. http://www.lens.org/images/patent/WO/2009109946/A1/WO_2009_109946_A1.pdf.
  32. Hammer, K.A., C.F. Carson and T.V. Riley, 1999. Antimicrobial activity of essential oils and other plant extracts. J. Appl. Microbiol., 86: 985-990.
    CrossRefPubMedDirect Link
  33. Haslam, E., T.H. Lilley, E. Warminski, H. Liao and Y. Cai et al., 1992. Polyphenol complexation: A study in molecular recognition. ACS Symp. Ser., 506: 8-50.
    CrossRefDirect Link
  34. Hattori, M., I.T. Kusumoto, T. Namba, T. Ishigami and Y. Hara, 1990. Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chem. Pharm. Bull., 38: 717-720.
    PubMed
  35. Hu, L., H. Wang, J. Pei and Y. Liu, 2010. Research progress of antitumor effects of resveratrol and its mechanism. Shandong Yiyao, 50: 111-112.
  36. Hu, Z.Q., N. Asano, Y. Yoda, Y. Hara and T. Shimamura, 2002. Epigallocatechin gallate synergistically enhances the activity of carbapens against methicillin resistant Staphylococcus aureus. Antimicrob. Agents Chem., 46: 558-560.
    CrossRef
  37. Hubert, B., L. Eberl, W. Feucht and J. Polster, 2003. Influence of polyphenols on bacterial biofilm formation and quorum-sensing. Z. Naturforsch., 58: 879-884.
    PubMed
  38. Iwu, M.M., A.R. Duncan and C.O. Okunji, 1999. New Antimicrobials of Plant Origin. In: Perspectives on New Crops and New Uses, Janick, J. (Ed.). ASHS Press, Alexandria, VA., USA., ISBN-13: 9780961502706, pp: 457-462.
    Direct Link
  39. Joyce, L.F., J. Downes, K. Stockman and J.H. Andrew, 1992. Comparison of five methods, including the PDM Epsilometer test (E test), for antimicrobial susceptibility testing of Pseudomonas aeruginosa. J. Clin. Microbiol., 30: 2709-2713.
    Direct Link
  40. Karou, D., W.MC. Nadembega, L. Ouattara, P.D. Ilboudo and A.S. Traore et al., 2007. African ethnopharmacology and new drug discovery. Med. Plant Sci. Biotechnol., 1: 61-69.
    Direct Link
  41. Kumar, S. and A.K. Pandey, 2012. Antioxidant, lipo-protective and antibacterial activities of phytoconstituents present in Solanum Xanthocarpum root. Int. Rev. Biophys. Chem., 3: 42-47.
    Direct Link
  42. Kumar, S. and A.K. Pandey, 2013. Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. Vegetos-Int. J. Plant Res., 26: 301-307.
    CrossRefDirect Link
  43. Kumar, S. and A.K. Pandey, 2013. Chemistry and biological activities of flavonoids: An overview. Sci. World J., Vol. 2013.
    CrossRefDirect Link
  44. Kumar, S. and A.K. Pandey, 2013. Phytochemicals Analysis, Cytotoxic and Radical Scavenging Activities of Parthenium Hysterophorus. In: Proceedings of International Conference on Health, Environment and Industrial Biotechnology (ICHEIB Bio Sangam 2013). November 21-23, 2013, Sharma, S. (Ed.). McGraw Hill Education (India) Pvt Ltd., Allahabad, India, New Delhi, ISBN-13: 9789332901377, pp: 271-274.
  45. Kumar, S., A. Mishra and A.K. Pandey, 2013. Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models. BMC Complementary Altern. Med., Vol. 13.
    CrossRefDirect Link
  46. Kumar, S., G. Chashoo, A.K. Saxena and A.K. Pandey, 2013. Parthenium hysterophorus: A probable source of anticancer, antioxidant and anti-HIV agents. BioMed Res. Int.
    CrossRefDirect Link
  47. Lampinen, J., 2005. Continuous Antimicrobial susceptibility testing in drug discovery. Drug Plus International, pp: 1-3. http://www.thermo.com/eThermo/CMA/PDFs/Various/File_30585.pdf.
  48. Liu, I. X., D. G. Durham and R. M. E. Richards, 2000. Baicalin synergy with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other β-lactam-resistant strains of S. aureus. J. Pharm. Pharmacol., 52: 361-366.
    CrossRefDirect Link
  49. Maple, P.A.C., J.M.T. Hamilton-Miller and W.C. Brumfitt, 1989. World-wide antibiotic resistance in methicillin-resistant Staphylococcus aureus. Lancet, 1: 537-540.
    CrossRefDirect Link
  50. Maurya, A., P. Chauhan, A. Mishra and A.K. Pandey, 2012. Surface functionalization of TiO2 with plant extracts and their combined antimicrobial activities against E. faecalis and E. coli. J. Res. Updates Polymer Sci., 1: 43-51.
    Direct Link
  51. Michalet, S., G. Cartier, B. David, A.M. Mariotte and M.G. Dijoux-Franca et al., 2007. N-Caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. Bioorg. Med. Chem. Lett., 17: 1755-1758.
    CrossRefDirect Link
  52. Mishra, A., A.K. Sharma, S. Kumar, A.K. Saxena and A.K. Pandey, 2013. Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant and anticancer activities. BioMed Res. Int.
    CrossRef
  53. Mishra, A.K., A. Mishra, A. Bhargava and A.K. Pandey, 2008. Anitmicrobial activity of essential oils of leaves of Cinnamomum spp. Natl. Acad. Sci. Lett., 31: 314-345.
  54. Mishra, A.K., A. Mishra, H.K. Kehri, B. Sharma and A.K. Pandey, 2009. Inhibitory activity of Indian spice plant Cinnamomum zeylanicum extracts against Alternaria solani and Curvularia lunata, the pathogenic dematiaceous moulds. Ann. Clin. Microbiol. Antimicrob., Vol. 8.
    CrossRefDirect Link
  55. Mishra, A.K., B.K. Singh and A.K. Pandey, 2010. In vitro-antibacterial activity and phytochemical profiles of Cinnamomum tamala (Tejpat) leaf extracts and oil. Rev. Infect., 1: 134-139.
  56. Mishra, A., S. Kumar and A.K. Pandey, 2013. Scientific validation of the medicinal efficacy of Tinospora cordifolia. Scient. World J.
    Direct Link
  57. Mishra, A., S. Kumar, A. Bhargava, B. Sharma and A.K. Pandey, 2011. Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants. Cell. Mol. Biol., 57: 16-25.
    PubMed
  58. Nascimento, G.G.F., J. Locatelli, P.C. Freitas and G.L. Silva, 2000. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Braz. J. Microbiol., 31: 247-256.
    CrossRefDirect Link
  59. Ncube, N.S., A.J. Afolayan and A.I. Okoh, 2008. Assessment techniques of antimicrobial properties of natural compounds of plant origin: Current methods and future trends. Afr. J. Biotechnol., 7: 1797-1806.
    CrossRefDirect Link
  60. Nelson, R., 1982. The comparative clinical pharmacology and pharmacokinetics of vindesine, vincristine and vinblastine in human patients with cancer. Med. Pediatr. Oncol., 10: 115-127.
    PubMed
  61. Nitha B., A.B. Remashree and I. Balachandran, 2012. Antibacterial activity of some selected indian medicinal plants. Int. J. Pharm. Sci. Res., 3: 2038-2042.
  62. Onawunmi, G.O., 2006. Prospects of Plant Products as Antimicrobial Agents. Obafemi Awolowo University Press Limited, Ile-Ife, Nigeria.
  63. Osbourn, A.E., 1996. Preformed antimicrobial compounds and plant defense against fungal attack. Plant Cell, 8: 1821-1831.
    CrossRefPubMedDirect Link
  64. Pandey, A.K., 2007. Anti-staphylococcal activity of a pan-tropical aggressive and obnoxious weed Parthenium histerophorus: An in vitro study. National Acad. Sci. Lett., 30: 383-386.
    Direct Link
  65. Pandey, A.K., A.K. Mishra and A. Mishra, 2012. Antifungal and antioxidative potential of oil and extracts derived from leaves of Indian spice plant Cinnamomum tamala. Cell. Mol. Biol., 58: 142-147.
    PubMed
  66. Pandey, A.K., A.K. Mishra, A. Mishra, S. Kumar and A. Chandra, 2010. Therapeutic potential of C. zeylanicum extracts: An antifungal and antioxidant perspective. Int. J. Biol. Med. Res., 1: 228-233.
    Direct Link
  67. Pandey, A.K., P. Pandey, S. Sharma and D.K. Maheshwari, 2005. Antibacterial potential of extracts of Lantana camara: A prominent weed of Northern India. Univ. J. Phytochem. Ayurvediv Heights, 1: 18-23.
  68. Pandey, A.K. and B. Sharma, 2011. Vaccines: Perspectives and Trends. In: Recent Trends in Biotechnology, Singh, M.P., A. Agrawal and B. Sharma (Eds.). Vol. 2. Nova Science Publishers, New York, USA., pp: 59-75.
  69. Parekh, J., D. Jadeja and S. Chanda, 2005. Efficacy of aqueous and methanol extracts of some medicinal plants for potential antibacterial activity. Turk. J. Biol., 29: 203-210.
    Direct Link
  70. Emma, N.Q., R.S. Antonio and A.V. Marta, 2001. Screening antifungal activities of selected medicinal plants. J. Ethnopharmacol., 74: 89-96.
    CrossRef
  71. Scheck, A.C., K. Perry, N.C. Hank and W.D. Clark, 2006. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. Biomed. Centr. Complement. Alternat. Med., Vol. 6.
    CrossRef
  72. Schelz, Z., J. Molnar and J. Hohmann, 2006. Antimicrobial and antiplasmid activities of essential oils. Fitoterapia, 77: 279-285.
    CrossRefPubMedDirect Link
  73. Schultes, R.E., 1978. The Kingdom of Plants. In: Medicines from the Earth, Thompson, W.A.R. (Ed.), McGraw-Hill Book Co., New York, pp:208.
  74. Shimizu, M., S. Shiota, T. Mizushima, H. Ito, T. Hatano, T. Yoshida and T. Tsuchiya, 2000. Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin. Agents Chemo., 45: 3198-3201.
    PubMed
  75. Stary, F., 1996. The Natural Guide to Medicinal Herbs and Plants. Barnes and Noble Inc., New York.
  76. Stermitz, F.R., P. Lorenz, J.N. Tawara, L.A. Zenewicz and K. Lewis, 2000. Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl. Acad. Sci., USA., 97: 1433-1437.
    PubMed
  77. Stockwell, C., 1988. Nature's Pharmacy. Century Hutchinson Ltd., London, UK.
  78. Talib, W.H., 2011. Anticancer and Antimicrobial Potential of Plant-Derived Natural Products. In: Phytochemicals-Bioactivities and Impact on Health. Rasooli, I., (Eds,). Intech publications, Croatia, pp: 141-158.
    CrossRefDirect Link
  79. Tanaka, J.C.A., C.C. da Silva, A.J.B. de Oliveira, C.V. Nakamura and B.P.D. Filho, 2006. Antibacterial activity of indole alkaloids from Aspidosperma ramiflorum. Braz. J. Med. Biol. Res., 39: 387-391.
    CrossRefDirect Link
  80. Taylor, J.L.S., T. Rabe, L.J. McGaw, A.K. Jäger and J. van Staden, 2001. Towards the scientific validation of traditional medicinal plants. Plant Growth Regul., 34: 23-37.
    CrossRefDirect Link
  81. Tegos, G., F.R. Stermitz, O. Lomovskaya and K. Lewis, 2002. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob. Agents Chemother., 46: 3133-3141.
    CrossRefDirect Link
  82. Tenover, F.C., J.M. Swenson, C.M. O'Hara and S.A. Stocker, 1995. Ability of commercial and reference antimicrobial susceptibility testing methods to detect vancomycin resistance in Enterococci. J. Clin. Microbiol., 33: 1524-1527.
    Direct Link
  83. Tiwari, P., B. Kumar, M. Kaur, G. Kaur and H. Kaur, 2011. Phytochemical screening and extraction: A review. Int. Pharm. Sci., 1: 98-106.
    Direct Link
  84. Vaghasiya, Y. and S.V. Chanda, 2007. Screening of methanol and acetone extracts of fourteen Indian medicinal plants for antimicrobial activity. Turk. J. Biol., 31: 243-248.
    Direct Link
  85. Van Etten, H.D., J.W. Mansfield, J.A. Bailey and E.E. Farmer, 1994. Two classes of plant antibiotics: Phytoalexins versus phytoanticipins. Plant Cell, 6: 1191-1192.
    CrossRefPubMedDirect Link
  86. Vichkanova, S.A., M.A. Rubinchik, V.V. Adgina and T.S. Fedorchenko, 1969. Study of the chemotherapeutic effect of sanguinarine. Farmakol. Toksikol., 32: 325-328.
  87. Walsh, C., 2000. Molecular mechanisms that confer antibacterial drug resistance. Nature, 409: 775-781.
    CrossRefDirect Link
  88. Zafriri, D., I. Ofek, R. Adar, M. Pocino and N. Sharon, 1989. Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells. Antimicrob. Agents Chem., 33: 92-98.
    Direct Link
  89. Ahn, J.W., S.U. Choi and C.O. Lee, 1994. Cytotoxic limonoids from Melia azedarach var. japonica. Phytochemistry, 36: 1493-1496.
    CrossRefDirect Link

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