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Pharmacologia
  Year: 2013 | Volume: 4 | Issue: 1 | Page No.: 22-33
DOI: 10.5567/pharmacologia.2013.22.33
 
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Impact of the Dopaminergic System on Mucosal Integrity in Indomethacin-induced Gastric Ulcers in Rats: Possible Modulation by Ranitidine or L-carnitine

Sally A. El-Awdan, Hala F. Zaki, Omar M. Abdel Salam, Wafaa I. El-Iraqy and Sanaa A. Kenawy

Abstract:
The present study aim to explore the impact of bromocriptine, or ziprasidone on rats mucosal integrity and the possible modulation by L-carnitine or ranitidine. Adult male Wistar rats were divided into 10 groups: the 1st and 2nd groups received 1% Tween 80 and served as normal and control groups, respectively. The remaining groups were treated as follows: 3-6 received bromocriptine (2.5 mg kg-1), L-carnitine (50 mg kg-1), ranitidine (50 mg kg-1) or ziprasidone (3 mg kg-1), respectively. Groups 7-10 received combinations of bromocriptine or ziprasidone with either L-carnitine or ranitidine. Drugs were daily administered (p.o.) for two weeks then all groups were subjected to pyloric ligation. Indomethacin (30 mg kg-1; p.o.) was immediately administered to all groups except the normal one. Rats were euthanized 4 h thereafter and stomachs were opened to evaluate the number and severity of the lesions. Gastric volume, acid output, peptic activity as well as mucin and gastric mucus concentrations were determined. Moreover, stomach content of lipid peroxides, reduced glutathione, nitric oxide metabolites and tumor necrosis factor were also estimated. Indomethacin administration resulted in increased ulcer index and severity that was coupled by increased titratable acidity, acid output and disturbance in antioxidant status. Such effects were intensified by ziprasidone and ameliorated by bromocriptine, L-carnitine or ranitidine. Moreover, administration of L-carnitine or ranitidine with ziprasidone attenuated its damaging effect. In conclusion, dopamine agonists play a significant role in maintenance of gastric mucosal integrity; meanwhile, dopamine antagonists complicate indomethacin-induced ulcers, an effect that could be mitigated by combined treatment with L-carnitine or ranitidine.
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How to cite this article:

Sally A. El-Awdan, Hala F. Zaki, Omar M. Abdel Salam, Wafaa I. El-Iraqy and Sanaa A. Kenawy, 2013. Impact of the Dopaminergic System on Mucosal Integrity in Indomethacin-induced Gastric Ulcers in Rats: Possible Modulation by Ranitidine or L-carnitine. Pharmacologia, 4: 22-33.

DOI: 10.5567/pharmacologia.2013.22.33

URL: https://scialert.net/abstract/?doi=pharmacologia.2013.22.33

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