Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2013.22.33El-AwdanSally A.ZakiHala F.SalamOmar M. AbdelEl-IraqyWafaa I.KenawySanaa A.1201341The present study aim to explore the impact of bromocriptine, or ziprasidone
on rats mucosal integrity and the possible modulation by L-carnitine or ranitidine.
Adult male Wistar rats were divided into 10 groups: the 1st and 2nd
groups received 1% Tween 80 and served as normal and control groups, respectively.
The remaining groups were treated as follows: 3-6 received bromocriptine (2.5
mg kg-1), L-carnitine (50 mg kg-1), ranitidine (50 mg
kg-1) or ziprasidone (3 mg kg-1), respectively. Groups
7-10 received combinations of bromocriptine or ziprasidone with either L-carnitine
or ranitidine. Drugs were daily administered (p.o.) for two weeks then all groups
were subjected to pyloric ligation. Indomethacin (30 mg kg-1; p.o.)
was immediately administered to all groups except the normal one. Rats were
euthanized 4 h thereafter and stomachs were opened to evaluate the number and
severity of the lesions. Gastric volume, acid output, peptic activity as well
as mucin and gastric mucus concentrations were determined. Moreover, stomach
content of lipid peroxides, reduced glutathione, nitric oxide metabolites and
tumor necrosis factor were also estimated. Indomethacin administration resulted
in increased ulcer index and severity that was coupled by increased titratable
acidity, acid output and disturbance in antioxidant status. Such effects were
intensified by ziprasidone and ameliorated by bromocriptine, L-carnitine or
ranitidine. Moreover, administration of L-carnitine or ranitidine with ziprasidone
attenuated its damaging effect. In conclusion, dopamine agonists play a significant
role in maintenance of gastric mucosal integrity; meanwhile, dopamine antagonists
complicate indomethacin-induced ulcers, an effect that could be mitigated by
combined treatment with L-carnitine or ranitidine.]]>Mafertheiner, P., F.K.L. Chan and K.E.L. McColl,200937414491461Hoogerwerf, W.A. and P.J. Pasricha,200111311324Vananenn, P.M., J.B. Medding and J.L. Wallace,1991261G470G475Bech, P.L., R. Xavier, N. Lu, N.N. Nanda, M. Dinauer, D.K. Podolsky and B. Seed,2000119699705Nemeroff, C.B., Lieberman J.A., Weiden P.J., Harvey P.D and J.W. Newcomer et al.,200510120Rashid, N., A. Ahmad, N. Singh, P. Singh and V. Mishra et al.,2010643121128Thorner, M.O.,19751662665Shay, H., S.A. Komarov, S.S. Fels, D. Meraze, M. Gruenstein and H. Siplet,194544361Mozsik, G., F. Moron and T. Javor,198297184Grossman, M.I.,1963115Brodie, D.A. and K.F. Hooke,19714193204Sanyal, A., O. Denath, S. Bhattacharya and K. Gode,19711971pp: 312-318pp: 312-318Corne, S.J., S.M. Morrissey and R.J. Woods,1974242116P117PWinzler, R.J.,19552279311Uchiyama, M. and M. Mishara,197886271278Beutler, E., O. Duron and B.M. Kelly,196361882888Miranda, K.M., M.G. Espey, K. Yamada, M. Krishna and N. Ludwick et al.,200127617201727Koracevic, D., G. Koracevic, V. Djordjevic, S. Andrejevic and V. Cosic,200154356361Tian, B., D.E. Nowak and A.A. Brasier,20052005Kaithwas, G. and D.K. Majumdar,2010Linum usitatissimum fixed oil and possible mechanism of action.]]>18137145Heeba, G.H., M.K.A. Hassan and R.S. Amin,2009607188193Albayrak, A., B. Polat, E. Cadirci, A. Hacimuftuoglu, Z. Halici and M. Gulapoglu et al.,201062113119Chattopadhyay, I., U. Bandyopadhyay, K. Biswas, P. Maity and R.K. Banerjee,20064013971408Altinkaynak, K., H. Suleyman and F. Akcay,200355645648Banerjee, D., A.K. Bauri, R.K. Guha, S.K. Bandyopadhya and S. Chattopadhyay,2008578300312Tripp, M.A. and B.L. Tepperman,1995115344348Calatayud, S., M.J. Sanz, A. Canet, R. Bello, F.D. de Rojas and J.V. Esplugues,199912711111118Caldara, R. and C. Barbieri,19871987pp: 232-242pp: 232-242Glavin, G.B. and S. Szabo,19903511531161Arafa, H.M.M. and M.M. Sayed-Ahmed,200348285290Erkin, B., D. Dokmeci, S. Altaner and F.N. Turan,2006488689Alam, S., M. Asad, S.M.B. Asdaq and V.S. Prasad,2009Momordica charantia L. in rats.]]>123464469Penissi, A.B. and R.S. Piezzi,199944708712De La Lastra, A., M.J. Martin and V. Motilva,1994485662Izgut-Uysal, V.N., M. Bulbul, R. Tan, N. Derin, I. Ustunel, A. Agar and P. Yargicoglu,200757187192Nunes, P.H., P.M. Cavalcanti, S.M. Galvao and M.C. Martins,2009645862Devi, R.S., S. Narayan, G. Vani and C.S. Shyamala-Devi,2007Terminalia arjuna bark on diclofenac sodium induced gastric ulcer.]]>1677183Izgut-Uysal, V.N., A. Agac and N. Derin,200136231236Muthuraman, A. and S. Sood,2010835560Gulcin, I.,200678803811Muthuswamy, A.D., K. Vedagiri, M. Ganesan and P. Chinnakannu,20063688492Kumaran, S., B. Deepak, B. Naveen, B. Naveen and C. Panneerselvam,20034141147Odabasoglu, F., A. Cakir, H. Suleyman, A. Aslan, Y. Bayir, M. Halici and C. Kazaz,20061035965Dengiz, G.O., F. Odabasoglu, Z. Halici, H. Suleyman, E. Cadirci and Y. Bayir,20073014261434Gurbuz, I. and E. Yesilada,2007Centaurea solstitialis L. ssp. solstitialis by using various In vivo and biochemical techniques.]]>112284291Kim, H. and K.H. Kim,200162200207Samini, M., L. Moezi, N. Jabarizadeh, B. Tavakolifar, H. Shafaroodi and A.R. Dehpour,200246519523Baraka, A.M., A. Guemei and H.A. Gawad,20107916341639Souza, M.H.L.P., H.P. Lemos, R.B. Oliveira and F.Q. Cunha,200453791796Dursun, H., M. Bilici, F. Albayrak, C. Ozturk, M.B. Saglam, H.H. Alp and H. Suleyman,20092009