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Journal of Pharmacology and Toxicology
  Year: 2010 | Volume: 5 | Issue: 8 | Page No.: 450-459
DOI: 10.3923/jpt.2010.450.459
 
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Evaluation of Safety of NaturalivTM Liquid and Zist® Liquid on Acute Oral Exposure in Rats

V. Vijayabalaji, J. Joshua Allan, G. Pavan Kumar, B. Murali, M.L. Suryanarayana and A. Amit

Abstract:
The objective of the current study was to assess the acute oral toxicity of some herbal veterinary preparations in female albino Wistar rats as per the OECD guidelines for testing of chemicals, Acute oral toxicity-Fixed dose procedure (Test guideline 420). The investigational substances, NaturalivTM liquid and Zist® liquid are used in poultry for hepatoprotective and antioxidant properties, respectively. NaturalivTM liquid was tested at 5000 mg kg-1 b.wt., whereas Zist® liquid was evaluated in sequential manner to one animal each at 2000 and 5000 mg kg-1 b.wt. in the sighting study, followed by four animals at 5000 mg kg-1 b.wt. in the main study. The treated animals were observed for mortality (twice daily), adverse clinical signs (once daily), changes in weekly body weight gain and gross necropsy findings. All the treated animals survived throughout the study period. Treatment with NaturalivTM liquid did not reveal any abnormal clinical signs at the tested dose level while Zist® liquid treated rats exhibited few clinical signs for a transient period on the day of dosing. The overall percent body weight gain in rats was found to be normal during the 14 day observation period. The terminal sacrifice revealed no gross pathological lesions that can be attributable to treatment. Based on this, it can be stated that NaturalivTM liquid and Zist® liquid, on single oral administration to female Wistar rats, were found to be safe up to 5000 mg kg-1 b.wt.
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How to cite this article:

V. Vijayabalaji, J. Joshua Allan, G. Pavan Kumar, B. Murali, M.L. Suryanarayana and A. Amit, 2010. Evaluation of Safety of NaturalivTM Liquid and Zist® Liquid on Acute Oral Exposure in Rats. Journal of Pharmacology and Toxicology, 5: 450-459.

DOI: 10.3923/jpt.2010.450.459

URL: https://scialert.net/abstract/?doi=jpt.2010.450.459

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