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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 5 | Page No.: 388-392
DOI: 10.3923/ijp.2008.388.392
 
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Acute Oral Toxicity Evaluation of Some Polyherbal Formulations in Albino Wistar Rats

A.J. Joshua, K.S. Goudar, A. Damodaran, N. Sameera and A. Amit

Abstract:
The present study was conducted to evaluate the acute oral toxicity potentials of certain herbal veterinary preparations in albino Wistar rats. In the sighting study, the test substances were administered in sequential manner to one animal each at 2000 and 5000 mg kg-1 body weight followed by four animals at 5000 mg kg-1 body weight in the main study; whereas the test materials with well documented traditional use were evaluated at 5000 mg kg-1 body weight. The treated animals were observed for mortality, untoward clinical/toxic signs, alterations in body weight gain and necropsy findings during the study. The treated animals survived throughout the study period and did not reveal any treatment related major abnormal clinical signs at the tested dose levels for all the products. The overall percent body weight gain in rats treated with the herbal products was found to be normal during the 14 day observation period. On necropsy, no abnormalities were observed. In conclusion, acute oral toxicity testing of screened herbal veterinary products did not produce any treatment-related adverse effects upto the dose level of 5000 mg kg-1 body weight.
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How to cite this article:

A.J. Joshua, K.S. Goudar, A. Damodaran, N. Sameera and A. Amit, 2008. Acute Oral Toxicity Evaluation of Some Polyherbal Formulations in Albino Wistar Rats. International Journal of Pharmacology, 4: 388-392.

DOI: 10.3923/ijp.2008.388.392

URL: https://scialert.net/abstract/?doi=ijp.2008.388.392

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