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Journal of Pharmacology and Toxicology
  Year: 2009 | Volume: 4 | Issue: 1 | Page No.: 1-16
DOI: 10.3923/jpt.2009.1.16
Antiaflatoxigenic Activities of Some Plant Aqueous Extracts Against Aflatoxin-B1 Induced Renal and Cardiac Damage
Azza M. Mohamed and Nadia S. Metwally

Abstract:
The present investigation aims at assessing the antiaflatoxigenic effect of aqueous extracts of some traditional medicinal plants (namely, Zingiber officinale Roscoe rhizome, Cinnamomum zeylanicum bark, Trigonella foenum graecum seeds, Camellia sinensis leaves and Salvia officinalis leaves) compared to the anticancer drug, methotrexate (MTX) against aflatoxin-B1 (AFB1) induced renal and cardiac damage in rats. The results revealed that administration of AFB1 induces oxidative stress in kidneys of AFB1-treated rats through elevating the level of malondialdehyde (MDA) and depleting the levels of tissue antioxidants, glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G-6-PDH) and vitamin C. The results also showed that aflatoxicosis interfere with the cellular energy supply of rat hearts through its inhibitory action on some markers of energy metabolism indicated by a decrease in glucose and glycogen contents of heart and a reduction in the activities of some glycolytic enzymes, phosphogluco-isomerase (PGI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) compared to normal healthy animals. Supplementation of the aqueous extracts of the above mentioned plants, effectively ameliorated the deviation induced in both kidneys and hearts of animals in response to AFB1 administration. This effect was evident through reducing MDA level and releasing the inhibitory effect of AFB1 on the levels of antioxidants in kidneys as well as on the energetic biomarkers in hearts. However, administration of MTX to AFB1-treated rats dramatically amplified the toxic effect of aflatoxicosis induced in both kidneys and hearts, indicated by marked increment in MDA level and decrease in the levels of antioxidants in kidneys of AFB1- MTX group in relation to AFB1-group, also a marked decrease in the bioenergetic markers in hearts of AFB1- MTX treated animals versus AFB1-treated ones was documented. From the current investigation, it can be concluded that supplementation of the extracts of the different plants presented in this study was beneficial in modulating the alterations induced in kidneys and hearts of rats under the effect of AFB1.
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