Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2009.1.16M. MohamedAzza S. MetwallyNadia 1200941The present investigation aims at assessing the antiaflatoxigenic
effect of aqueous extracts of some traditional medicinal plants (namely,
Zingiber officinale Roscoe rhizome, Cinnamomum zeylanicum
bark, Trigonella foenum graecum seeds, Camellia sinensis
leaves and Salvia officinalis leaves) compared to the anticancer
drug, methotrexate (MTX) against aflatoxin-B1 (AFB1) induced renal and
cardiac damage in rats. The results revealed that administration of AFB1
induces oxidative stress in kidneys of AFB1-treated rats through elevating
the level of malondialdehyde (MDA) and depleting the levels of tissue
antioxidants, glutathione reductase (GR), glucose-6-phosphate dehydrogenase
(G-6-PDH) and vitamin C. The results also showed that aflatoxicosis interfere
with the cellular energy supply of rat hearts through its inhibitory action
on some markers of energy metabolism indicated by a decrease in glucose
and glycogen contents of heart and a reduction in the activities of some
glycolytic enzymes, phosphogluco-isomerase (PGI), glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) compared to normal
healthy animals. Supplementation of the aqueous extracts of the above
mentioned plants, effectively ameliorated the deviation induced in both
kidneys and hearts of animals in response to AFB1 administration. This
effect was evident through reducing MDA level and releasing the inhibitory
effect of AFB1 on the levels of antioxidants in kidneys as well as on
the energetic biomarkers in hearts. However, administration of MTX to
AFB1-treated rats dramatically amplified the toxic effect of aflatoxicosis
induced in both kidneys and hearts, indicated by marked increment in MDA
level and decrease in the levels of antioxidants in kidneys of AFB1- MTX
group in relation to AFB1-group, also a marked decrease in the bioenergetic
markers in hearts of AFB1- MTX treated animals versus AFB1-treated ones
was documented. From the current investigation, it can be concluded that
supplementation of the extracts of the different plants presented in this
study was beneficial in modulating the alterations induced in kidneys
and hearts of rats under the effect of AFB1.]]>Abdel-Wahhab, M.A. and S.E. Aly,20035124092414Afzal, M., D. Al-Hadidi, M. Menon, J. Pesek and M.S.I. Dhami,200118159190Ahmed, I., A. John, C. Vijayasarathy, M.A. Robin and H. Raza,200223289300Ajith, T.A., U. Hema and M.S. Aswathy,2007Zingiber officinale roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status.]]>4522672272Ajith, T.A., V. Nivitha and S. Usha,2007Zingiber officinale roscoe alone and in combination with a-tocopherol protect kidney against cisplatin induced acute renal failure.]]>45921927Almajano, M.P., R. Carbo, J.A.L. Jimenez and M.H. Gordon,20081085563Al-Qattan, K., M. Thomson and M. Ali,2008Allium sativum) and ginger (Zingiber officinale) attenuate structural nephropathy progression in streptozotocin-induced diabetic rats.]]>3e62e71Amin, A. and A.A. Hamza,2005Hibiscus, Rosmarinus and salvia on azathioprine-induced toxicity in rats]]>77266278Anderson, R.A., C.L. Broadhurst, M.M. Polansky, W.F. Schmidt and A. Khan et al.,2004526570Anderson, R.A., J.H. Brantne and M.M. Polansky,19782612191221Anilakumar, K.R., N.S. Nagaraj and K. Santhanam,200424313319Antunes, N.L., M.M. Souweidane, E. Li, M.K. Rosenblum and P.G. Steinherz,200226305308Babiak, R.M., A.P. Campello, E.G. Carnieri and M.B. Oliveira,199816283293Bennett, J.W. and M. Klich,200316497516Berg, D., M.B. Youdim and P. Riederer,2004318201213Bergmeyer, H.U.,197513269269Bergmeyer, H.U., E. Bernt, M. Grassl and G. Michel,19741974pp: 458-459pp: 458-459Bintvihok, A.,200262829Bonsi, P., G. Augusti-Tocco, M. Palmery and M. Giorgi,199932615619Breimer, L.H., 19903188197Brock, S. and H.R. Jenning,200424673676Brooks, S.P.J., K.A. Cockell, B.A. Dawson, W.M.N. Ratnayake and B.J. Lampi et al.,200314648655Buege, J.A. and S.D. Aust,19781978pp: 302-310pp: 302-310Caetano, N.N., A.P. Campello, E.G.S. Carnieri, M.L.W. Kluppel and M.B.M. Oliveira,199715259264Cao, E.H., X.Q. Liu, J.J. Wang and N.F. Xu,199620801806Cetiner, M., G. Sener, A.O. Sehirli, E. Eksioglu-Demiralp and F. Ercan et al.,20052093950Carvajal, K. and R.M. Sánchez,2003348999Chen, J.H., G.L. Topoe, E.C. Liong, H.S.H. So and K.M. Leung et al.,200480742751Chou, F.P., Y.C. Chu, J.D. Hsu, H.C. Chiang and C.J. Wang,2000S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver.]]>60643650Cherevatyi, V.S., T.N. Vashhenko and G.Z. Shishkov,1980Salvia officinalis.]]>16137139Davey, M.W., M. Van Montagu, D. Inze, M. Sanmartin and A. Kanellis et al.,200080825860Dixit, P., S. Ghaskadbi, H. Mohan and T.P. Devasagayam,200519977983Doan, T. and E. Massarotti,200545751762Dorman, H.J.D., A.C. Figueiredo, J.G. Barroso and S.G. Deans,2000In vitro evaluation of antioxidant activity of essential oils and their components.]]>151216Dufresne, C.J. and E.R. Farnworth,200112404421Eidi, M., A. Eidi and H. Zamanizadeh,2005Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats.]]>100310313Erden, M. and N.M. Bor,198431217227Farag, R.S., F.L. Salem, A.Z.M.A. Badei and D.E. Hassanein,1986886972Fink-Gremmels, J.,199921115120Fung, K.P., S.W. Ng, W.P. Lam and Y.M. Choy,198618759767Gali-Muhtasib, H., C. Hilan and C. Khater,2000Salvia libanotica (East Mediterranean sage) and the effects of its essential oils.]]>71513520Gupta, R. and S. Nair,199938394Hohmann, J., I. Zupko, D. Redei, M. Csanyi, G. Falkay, I. Mathe and G. Janicsak,1999Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation.]]>65576578Huang, Y.S. and J.T. Zhang,1992Salvia miltiorrhiza in vitro.]]>2796100Ito, Y., S. Ohnishi and K. Fujie,1989in vivo and their suppression by green tea.]]>222253261Jagota, S.K. and H.M. Dani,1982127178182Jahovic, N., H. Cevik, A.O. Sehirli, B.C. Yegen and G. Sener,200334282287Jarvill-Taylor, K.J., R.A. Anderson and D.J. Graves,200120327336Joseph, G.S., G.K. Jayaprakasha, A. Tamil Selvi, B.S. Jena and K.K. Sakariah,2005101153160Kannappan, S. and C.V. Anuradha,200832216233Kannappan, S., T. Jayaraman, P. Rajasekar, M.K. Ravichandran and C.V. Anuradha,200647858863Kaviarasan, S., R. Sundarapandiyan and C.V. Anuradha,2008Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver.]]>24391400Kiessling, K.H.,198658327338Kumar, R., A.K. Mishra, N.K. Dubey and Y.B. Tripathi,2007115159164Lantza, R.C., G.J. Chena, M. Sarihana, A.M. So-lyomb and S.D. Joladb,200714123128Lee, H.S., E.Y. Seo, N.E. Kang and W.K. Kim,200819313319Lee, J.S., S.M. Jeon, E.M. Park, T.L. Huh, O.S. Kwon, M.K. Lee and M.S. Choi,20036183191Lee, T., L. Mai, G. Wang, J. Chiu and Y. Lin,2003Salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats.]]>91202210Jodynis-Liebert, J., I. Matlawska, W. Bylka and M. Murias,2006Aquilegia vulgaris L. on aflatoxin B1-induced hepatic damage in rats.]]>225863Liu, J., H. Shen and C. Ong,20001538593Liu, J., C. Yang, S. Wasser, H. Shen, C. Tan and C. Ong,200169309326Mancini, D., A. Benaminovitz, M.E. Cordisco, R.N.W. Karmally and R.D.A. Weinberg,19993418071812Masuda, Y., H. Kikuzaki, M. Hisamoto and N. Nakatani,200421293296Taha, A., K. Akhtar, R.N.K. Bamezai, N.Z. Baquer and S. Mohammad,2006In vivo effect of Trigonella foenum graecum on the expression of pyruvate kinase, phosphoenolpyruvate carboxykinase and distribution of glucose transporter (GLUT4) in alloxan-diabetic rats.]]>84647654Miyazono, Y., F. Gao and T. Horie,20043911191127Nardini, M., F. Natella, V. Gentili, M. Difelice and C. Scaccini,1997in vivo study.]]>342157160Naaz, F., S. Javed and M.Z. Abdin,2007Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice.]]>113503509Carroll, N.V., R.W. Longley and J.H. Roe,1956220583593Niki, E., Y. Yoshida, Y. Saito and N. Noguchi,2005338668676Oh, S., J. Nan, D. Sohn, Y. Kim and B. Lee,20021822733Pandey, R.,2003388486Suja Pandiana, R., C.V. Anuradha and P. Viswanathan,2002Trigonella foenum graecum) on experimental gastric ulcer in rats.]]>81393397Pasha, T.N., M.U. Farooq, F.M. Khattak and M.A. Jabbar,2006132103110Panza, V.S.P., E. Wazlawik, G.R. Schutz, L. Comin, K.C. Hecht and E.L. Da-Silva,200824433442Pizzale, L., R. Bortolomeazzi, S. Vichi, E. Uberegger and L.C. Conte,2002Salvia officinalis and S. fruticosa) and oregano (Origanum onites and O. indercedens) extracts related to their phenolic compound content.]]>8216451651Preetha, S.P., M. Kanniappan, E. Selvakumar, M. Nagaraj and P. Varalakshmi,2006143333339Preston, R.J. and G.M. Williams,200535673683Puri, D., K.M. Prabhu and P.S. Murthy,200246457462Rajamani, R., A. Muthuvel, M. Senthilvelan and R. Sheeladevi,2006165265273Raju, J., D. Gupta, A.R. Rao, P.K. Yadava and N.Z. Baquer,2001Trigonella foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes.]]>2244551Raza, H. and A. John,2005207212220Rodrıguez, A., R. Batlle and C. Nerın,2007603338Rofe, A.M., C.S. Bourgeois, J.M. Washington, J.C. Philcox and P. Coyle,1994724348Salunkhe, D.K., R.N. Adsule and D.N. Padule,19871987Sener, G., E.E. Demiralp, M. Cetiner, F. Ercan and B. Yegen,2006542170178Serrano, A., M.I. Mateos and M. Losada,199118110771083Shang, M., S. Cai, J. Han, J. Li, Y. Zhao and J. Zheng,1998Trigonella foenum graecum L).]]>23614639Sharma, R.D.,1986613531364Sharma, R.D., A. Sarkar, D.K. Hazra, B. Misra, J.B. Singh, B.B. Maheshwari and S.K. Sharma,199610332334Sharma, R.A. and P.B. Farmer,20041049014912Sies, H. and W. Stahl,1995621315S1321SSingh, G., S. Maurya, M.P. de Lampasona and C.A.N. Catalan,20074516501661Sur, P., M. Das, A. Gomes, J.R. Vedasiromoni and N.P. Sahu, et al.,2001Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent.]]>15257259Tessari, E.N., C.A. Oliveira, A.L. Cardoso, D.R. Ledoux and G.E. Rottinghaus,20061 and fumonisin B1 on body weight, antibody titres and histology of broiler chicks.]]>47357364Tessier, J.P., B. Thurner, E. Jungling, A. Luckhoff and Y. Fischer,200360119130Thomson, M., K. Al-Qattan, M. Al-Sawan, M.M. Alnaqeeb, I. Khan and M. Ali,2002Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent.]]>67475478Thongson, C., P.M. Davidson, W. Mahakarnchanakul and J. Weiss,2004Solvent-extracted spices.]]>39401406Towner, R.A., S.Y. Qian, M.B. Kadiiska and R.P. Mason,2003In vivo identification of aflatoxin-induced free radicals in rat bile]]>3513301340Trinder, P.,196962427Tulayakul, P., K.S. Dong, J.Y. Li, N. Manabe and S. Kumagai,2007in vitro metabolism of aflatoxin B1 by their tissues.]]>50339348Uzar, E., O. Sahin, R.H. Koyuncuoglu, E. Uz and O. Bas et al.,2006218125133Verma, R.J. and A. Nair,199927223226Walker, T.M., P.C. Rhodes and C. Westmoreland,200014475485Wang, A., S. Sha, W. Lesniak and J. Schacht,2003Salvia miltiorrhizae extract) preparations attenuate aminoglycosideinduced free radical formation in vitro and ototoxicity in vivo.]]>4718361841Wangikar, P.B., P. Dwivedi, N. Sinha, A.K. Sharma and A.G. Telang,20051 with special reference to microscopic effects.]]>2153747Wogan, G.N.,199930573575Wu, R. and E. Racker,195923410291035Zhang, Z., K. Apse, J. Pang and R.C. Stanton,20002754004240047Zheng, W. and S.Y. Wang,20014951655170Zupko, I., J. Hohmann, D. Redei, G. Falkay, G. Janicsak and I. Mathe,2001Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents.]]>67366368