Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2008 | Volume: 3 | Issue: 4 | Page No.: 279-290
DOI: 10.3923/jpt.2008.279.290
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Combinational Effect of Green Tea, Phytic Acid and Inositol on Bone Mineralization and Mineral Balance in with Azoxymethane-Induced Colon Carcinogenesis Induced Fisher 344 Male Rats

R. Sunkara, M.Verghese , J. Khatiwada , L. Shackelford , J. Boateng , L.T. Walker and C.B. Chawan

Abstract:
The aim of the study was to determine the combinational effect of dietary Phytic Acid (PA), Green Tea (GT) and Inositol (I) at 1 and 2% level (in drinking water) on bone mineralization in rats with azoxymethane (AOM)-induced colon carcinogenesis. After one week period of acclimatization, 9 groups of rats (6 rats each) were fed AIN 93G (till 20 week) and later switched to AIN 93 M diets (till 45 weeks age). All rats received AOM s/c at the rate of 16 mg kg-1 body weight at 7 and 8 weeks of age. Urine and fecal samples were collected for a 12 day period. Rats were killed by CO2 asphyxiation at 46 week of age and samples (cecum, blood, tibia and femur) were collected and analyzed by ICP for selected minerals (Ca, P, Mg, Fe and Zn). Physical parameters (weight, length, circumference and volume) of tibia and femur were examined. There were no significant differences in apparent absorption, retention and serum concentrations of macro minerals (Ca, P and Mg), although apparent absorption, bone and serum levels of Fe and Zn were significantly lower in 2% combinations. Results of this study showed that combination of treatments at lower levels may be beneficial in reducing the negative effects on bone mineralization.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Expression of Membranous Epidermal Growth Factor Receptor in Colorectal Adenocarcinoma and It ’ s Correlation with Clinicopathological Features
How to cite this article:

R. Sunkara, M.Verghese , J. Khatiwada , L. Shackelford , J. Boateng , L.T. Walker and C.B. Chawan, 2008. Combinational Effect of Green Tea, Phytic Acid and Inositol on Bone Mineralization and Mineral Balance in with Azoxymethane-Induced Colon Carcinogenesis Induced Fisher 344 Male Rats. Journal of Pharmacology and Toxicology, 3: 279-290.

DOI: 10.3923/jpt.2008.279.290

URL: https://scialert.net/abstract/?doi=jpt.2008.279.290

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom