Submit Manuscript

Pakistan Journal of Biological Sciences

Year: 2011 | Volume: 14 | Issue: 5 | Page No.: 357-362
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 122

Authors

G. Mohammadi

K. Jamialahmadi

S. Lary

K. Ghaffarzadegan

Keywords

Research Article

Expression of Membranous Epidermal Growth Factor Receptor in Colorectal Adenocarcinoma and It ’ s Correlation with Clinicopathological Features

G. Mohammadi, K. Jamialahmadi, S. Lary and K. Ghaffarzadegan
The aim of this study was to investigate the expression of membranous epidermal growth factor receptor in colorectal adenocarcinoma and it’s correlation with clinicopathological features. Fifty formalin-fixed, paraffin embedded archival specimens of colorectal cancer were included randomly as cases. Immunohistochemical staining was performed to assess EGFR expression. The results were correlated with the clinicopathological features of colorectal tumor tissues. More than 1% of membranous EGFR expression was found in 24 (48%) of cancer specimens. The immunoreactions intensity was classified as weak, moderate and strong representing 2, 22 and 24%, respectively. According to multivariate analysis, EGFR expression was not significantly associated with age, sex, tumor site, stage, grade and type of tumor in cases. These results suggest that the assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry has not proven its predictive value and can not be useful to predict about outcome of patients.
PDF Fulltext XML References Citation

Related Articles

Expressions of Epidermal Growth Factor Receptor, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Bladder Carcinoma
Probiotics: A New Popular Option for Cancer Inhibition
Combinational Effect of Green Tea, Phytic Acid and Inositol on Bone Mineralization and Mineral Balance in with Azoxymethane-Induced Colon Carcinogenesis Induced Fisher 344 Male Rats
Expression of Macrophage Inhibitory Cytokine-1 in Benign and Malignant Prostatic Tissues: Implications for Prostate Carcinogenesis and Progression of Prostate Cancer
Progesterone Receptor Positive Colorectal Tumors Have Lower Thymidine Phosphorylase Expression: An Immunohistochemical Study

Leave a Comment

Your email address will not be published. Required fields are marked *