Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 5 | Page No.: 357-362
DOI: 10.3923/pjbs.2011.357.362
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Expression of Membranous Epidermal Growth Factor Receptor in Colorectal Adenocarcinoma and It ’ s Correlation with Clinicopathological Features

G. Mohammadi, K. Jamialahmadi, S. Lary and K. Ghaffarzadegan

Abstract:
The aim of this study was to investigate the expression of membranous epidermal growth factor receptor in colorectal adenocarcinoma and it’s correlation with clinicopathological features. Fifty formalin-fixed, paraffin embedded archival specimens of colorectal cancer were included randomly as cases. Immunohistochemical staining was performed to assess EGFR expression. The results were correlated with the clinicopathological features of colorectal tumor tissues. More than 1% of membranous EGFR expression was found in 24 (48%) of cancer specimens. The immunoreactions intensity was classified as weak, moderate and strong representing 2, 22 and 24%, respectively. According to multivariate analysis, EGFR expression was not significantly associated with age, sex, tumor site, stage, grade and type of tumor in cases. These results suggest that the assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry has not proven its predictive value and can not be useful to predict about outcome of patients.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Expressions of Epidermal Growth Factor Receptor, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Bladder Carcinoma
  •    Probiotics: A New Popular Option for Cancer Inhibition
  •    Combinational Effect of Green Tea, Phytic Acid and Inositol on Bone Mineralization and Mineral Balance in with Azoxymethane-Induced Colon Carcinogenesis Induced Fisher 344 Male Rats
  •    Expression of Macrophage Inhibitory Cytokine-1 in Benign and Malignant Prostatic Tissues: Implications for Prostate Carcinogenesis and Progression of Prostate Cancer
How to cite this article:

G. Mohammadi, K. Jamialahmadi, S. Lary and K. Ghaffarzadegan, 2011. Expression of Membranous Epidermal Growth Factor Receptor in Colorectal Adenocarcinoma and It ’ s Correlation with Clinicopathological Features. Pakistan Journal of Biological Sciences, 14: 357-362.

DOI: 10.3923/pjbs.2011.357.362

URL: https://scialert.net/abstract/?doi=pjbs.2011.357.362

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom