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Research Journal of Parasitology
  Year: 2011 | Volume: 6 | Issue: 2 | Page No.: 60-73
DOI: 10.3923/jp.2011.60.73
 
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Toxoplasma gondii Strategy for Intracellular Survival: Is it Still Enigmatic?
Magda M. Sanad and Ebtesam M. AL Olayan

Abstract:
Toxoplasma gondii has been considered as one of the most successful models for intracellular parasitism. Throughout the last two decades, considerable progress has been made to clarify the obscurity of both pathogenicity and long-lasting chronicity of toxoplasmosis. The recent integration of the many sources of genomic, proteomic and metabolomic data has allowed good clarification of the molecular details of the parasite-dependent effects for Toxoplasma-infected cells. Mechanisms of host-cell invasion, intracellular survival, stage-conversion of the slow-growing bradyzoite within long-lasting tissue cysts to a rapidly replicating highly pathogenic tachyzoite and vice versa, structure and composition of the apical organelles, subversion of inflammatory host response by the parasite, interference with effector functions of immune cells, evasion of host immune defenses, modulation of host cell apoptosis and the recent achievements in the use of lipid synthetic pathways by the parasite etc., all have been recently highlighted but still in need for further elucidation. This review offers a brief declaration of the progress that has been made to understand the curious intimate relationship between Toxoplasma gondii and its host cell.
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How to cite this article:

Magda M. Sanad and Ebtesam M. AL Olayan, 2011. Toxoplasma gondii Strategy for Intracellular Survival: Is it Still Enigmatic?. Research Journal of Parasitology, 6: 60-73.

DOI: 10.3923/jp.2011.60.73

URL: https://scialert.net/abstract/?doi=jp.2011.60.73

 
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