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Research Journal of Parasitology
  Year: 2006 | Volume: 1 | Issue: 1 | Page No.: 42-47
DOI: 10.3923/jp.2006.42.47
 
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Susceptibility of Artificially Released Zoites of Toxoplasma gondii, to Gamma Irradiation
A. Freyre, J. Falcon , J. Mendez , M. Gonzalez and S. Lanzzeri

Abstract:
Bioassay in mice revealed, that tachyzoites, bradyzoites and sporozoites that had not been manipulated or artificially separated from their natural environment, were capable of resisting a dose of 250 Gy, whereas tachyzoites of a strain of Toxoplasma of low pathogenicity for mice (ME- 49), obtained by culture in the peritoneal cavity of immunodeppressed mice, sporozoites artificially released from oocysts and bradyzoites artificially released from brain tissue cysts, resisted doses of only 150 and 100 Gy, respectively. These irradiated zoites were able to protect mice against infection and brain cyst formation. It is important to ascertain the sublethal dose of γ irradiation of zoites of Toxoplasma gondii for experimental immunization, so that zoites are capable of penetrating host cells without further multiplication, to elicit immunity without persisting in the host tissues.
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How to cite this article:

A. Freyre, J. Falcon , J. Mendez , M. Gonzalez and S. Lanzzeri , 2006. Susceptibility of Artificially Released Zoites of Toxoplasma gondii, to Gamma Irradiation. Research Journal of Parasitology, 1: 42-47.

DOI: 10.3923/jp.2006.42.47

URL: https://scialert.net/abstract/?doi=jp.2006.42.47

 
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